Publications by authors named "Chelsea Munster"
Objective: This study aimed to describe the evolution of amplitude-integrated electroencephalography (aEEG) in neonatal encephalopathy (NE) during therapeutic hypothermia (TH) and evaluate the association between aEEG parameters and magnetic resonance imaging (MRI) injury.
Study Design: aEEG data of infants who underwent TH were reviewed for background, sleep wake cycling (SWC), and seizures. Conventional electroencephalography (cEEG) background was assessed from the reports.
Bohring-Opitz syndrome (BOS) is a rare genetic condition caused by pathogenic variants in ASXL1, which is a gene involved in chromatin regulation. BOS is characterized by severe intellectual disabilities, distinctive facial features, hypertrichosis, facial nevus simplex, severe myopia, a typical posture in infancy, variable anomalies, and feeding issues. Wilms tumor has also been reported in two individuals.
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- Premature infants with extremely low gestational age (<29 weeks) are at risk for brain injuries due to irregular blood flow in their brains, which can lead to serious conditions like germinal matrix/intraventricular hemorrhage (GM/IVH).
- Continuous monitoring of cerebral blood flow (CBF) using diffuse correlation spectroscopy (DCS) shows promise in assessing these infants, correlating well with scalp blood flow measurements.
- In a study of 19 ELGA infants, a strong connection was found between CBF and scalp blood flow in cases of severe IVH, suggesting this method can help quickly identify infants at risk for brain injury.
Background: The incidence of cerebral sinovenous thrombosis (CSVT) in infants receiving therapeutic hypothermia for neonatal encephalopathy remains controversial. The aim of this study was to identify if the routine use of magnetic resonance venography (MRV) in term-born infants receiving hypothermia is associated with diagnostic identification of CSVT.
Methods: We performed a retrospective review of 291 infants who received therapeutic hypothermia from January 2014 to March 2020.
Objective: To assess the association between cerebral saturation (crSO) using Near-Infrared Spectroscopy (NIRS) and brain injury in extremely preterm infants.
Study Design: This retrospective study includes 62 infants (<28 weeks gestation) who underwent continuous NIRS monitoring in the first 5 days after birth. Median crSO were compared in 12 h increments between infants with and without germinal matrix/intraventricular hemorrhage (GM/IVH).
Objective: To evaluate the association between hypocapnia within the first 24 h of life and brain injury assessed by a detailed MRI scoring system in infants receiving therapeutic hypothermia (TH) for neonatal encephalopathy (NE) stratified by the stage of NE.
Study Design: This retrospective cohort study included infants who received TH for mild to severe NE.
Results: 188 infants were included in the study with 48% having mild and 52% moderate-severe NE.
Background: Therapeutic hypothermia (TH) is routinely provided to those with moderate or severe neonatal encephalopathy (NE). Subtle differences exist in the standardized exams used to define NE severity. We aimed to assess if an infant's TH eligibility status differed if they were evaluated using either the NICHD/Neonatal Research Network's (NICHD-NRN) or TOBY/British Association of Perinatal Medicine's (TOBY-BAPM) neurological exam.
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- The NICHD and SIBEN assessments are evaluated for their effectiveness in identifying the severity of neonatal encephalopathy (NE) and determining the threshold for significant brain injury in newborns.
- A study involving 145 infants with varying degrees of NE showed a high level of agreement between the two grading systems, although SIBEN classified more infants as moderate than NICHD did.
- Both SIBEN and NICHD numerical scores were found to be better than standard grades at predicting brain injury, suggesting further research is needed to understand their long-term outcome predictive capabilities.
Objective: The use of supplemental oxygen in premature infants is essential for survival. However, its use has been associated with unintended complications. The restricted use of oxygen is associated with increased mortality and necrotizing enterocolitis (NEC), whereas its liberal use is associated with increased risk for retinopathy of prematurity (ROP).
View Article and Find Full Text PDFAim: To investigate the characteristics of infants with neonatal encephalopathy (NE) receiving therapeutic hypothermia (TH) who developed late onset oxygen requirement during or after rewarming.
Methods: Infants were stratified by receiving (a) new onset isolated oxygen requirements during or after rewarming; (b) no respiratory support during hospital stay; and (c) invasive and/or non-invasive respiratory support before or during cooling.
Results: Of 136 infants treated with TH, 49 (36%) did not require any respiratory support, and 78 (57.