Publications by authors named "Chelsea M Peterson"
Article Synopsis
- CCR5 KO kidney transplant recipients produce significantly more alloantibodies and show pathology similar to human antibody-mediated rejection (AMR).
- In experiments with CCR5 KO and C57BL/6 mice receiving A/J kidneys, it was found that CCR5 KO recipients had four times the alloantibody levels and a notable deficiency in CXCR5 CD8 T cells compared to C57BL/6 mice.
- Adoptive cell therapy (ACT) using alloprimed CXCR5 CD8 T cells effectively reduced alloantibody levels, improved AMR pathology, and extended the survival of the transplanted kidneys in CCR5 KO recipients, suggesting a potential therapeutic approach for managing high alloantibody responses.
Hepatocyte transplant represents a treatment for metabolic disorders but is limited by immunogenicity. Our prior work identified the critical role of CD8 T cells, with or without CD4 T cell help, in mediating hepatocyte rejection. In this study, we evaluated the influence of invariant NKT (iNKT) cells, uniquely abundant in the liver, upon CD8-mediated immune responses in the presence and absence of CD4 T cells.
View Article and Find Full Text PDFAlthough almost all mycobacterial species are saprophytic environmental organisms, a few, such as , have evolved to cause transmissible human infection. By analyzing the recent emergence and spread of the environmental organism through the global cystic fibrosis population, we have defined key, generalizable steps involved in the pathogenic evolution of mycobacteria. We show that epigenetic modifiers, acquired through horizontal gene transfer, cause saltational increases in the pathogenic potential of specific environmental clones.
View Article and Find Full Text PDF