Am J Health Syst Pharm
November 2024
Background: There are few studies describing aminoglycoside pharmacokinetics during continuous renal replacement therapy (CRRT).
Objective: To characterize the effect of CRRT on aminoglycoside clearance and volume of distribution ().
Methods: Retrospective observational pharmacokinetic study of adult critically ill oncologic patients who received a first dose of amikacin or tobramycin during CRRT between February 2012 and May 2017.