Publications by authors named "Chelliah Bharkavi"
Article Synopsis
- The text discusses a one-pot, microwave-assisted process for creating new dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-tetraone derivatives through a three-component reaction involving azomethine ylides and 1-aryl-1H-pyrrole-2,5-diones.
- The synthesized compounds were tested for their effectiveness against mycobacterial infections and their ability to inhibit acetylcholinesterase (AChE).
- Notably, compound 4b showed significant antimycobacterial activity, being 12 times more effective than cycloserine, while compound 4h demonstrated strong AChE inhibitory properties
A facile stereoselective synthesis of novel dispiro indeno pyrrolidine/pyrrolothiazole-thiochroman hybrids has been achieved by 1,3-dipolar cycloaddition of azomethine ylides, generated in situ from ninhydrin and sarcosine/thiaproline, on a series of 3-benzylidenethiochroman-4-ones. The synthesised compounds were screened for their antimycobacterial, anticancer and AchE inhibition activities. Compound 4l (IC 1.
View Article and Find Full Text PDFA library of novel dispiro compounds containing oxindole pyrrolidine/oxindolopyrrolothiazole-thiochroman-4-one hybrid frameworks has been synthesized in a fully regio- and stereoselective fashion by the three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the condensation of isatins and secondary amino acids (sarcosine/l-thioproline) with 3-arylidenethiochroman-4-ones. This experimentally simple protocol provides good yields of structurally complex, biologically relevant heterocycles in a single operation.
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