Publications by authors named "Cheli Kambaran"
Article Synopsis
- - Regulatory T cells (Tregs) are crucial for maintaining tissue balance, with a study in Nairobi revealing a significant correlation between Treg levels in the endocervix and blood in women, highlighting a higher frequency of Tregs in the endocervix.
- - Most Tregs in both tissues expressed the FOXP3 marker, and endocervical Tregs showed higher CTLA-4 levels compared to blood, which might indicate enhanced functionality in this area.
- - The study suggests that increasing endocervical Treg proportions could potentially help lower inflammation in the genital tract, as higher Treg levels were linked to decreased pro-inflammatory cytokines and lower CD4+ T cell abundance in the endocervix
Sex Work Is Associated With Increased Vaginal Microbiome Diversity in Young Women From Mombasa, Kenya.
J Acquir Immune Defic Syndr
September 2020
Background: Although nonoptimal vaginal bacteria and inflammation have been associated with increased HIV risk, the upstream drivers of these phenotypes are poorly defined in young African women.
Setting: Mombasa, Kenya.
Methods: We characterized vaginal microbiome and cytokine profiles of sexually active young women aged 14-24 years (n = 168) in 3 study groups: those engaging in formal sex work, in transactional sex, and nonsex workers.