[Toxicology and hygienic regulation of lithium and its salts in the air of work areas].

Lithium salts can impair the central nervous system and kidney function and disturb the biological oxidation as well as desamidization of biologically active amines. The suggested MAC for lithium and its salts in the air of working area is 0.05 mg/m3 (aerosol, 2nd jeopardy grade).

[Pathogenetic therapy of cobalt-induced cardiomyopathies].

The pathogenesis of damage to the heart muscle caused by exposure to the effect of cobalt compounds is demonstrated. Agents with various mechanisms of action were tested in the experiment. The most effective pharmacological agents (beta-adrenergic blocking agents, anabolic steroids) are recommended for testing in the clinic.

[Mechanism of the cardiotoxic effect of various industrial poisons (metals)].

The effect of acute and repeated action of cobalt, lead, antimony on the metabolism of the heart muscle is shown. High doses of the metals of approximately 1/5 LD50 were studied in the acute experiment and doses one fifth these in the repeated experiment. The data obtained indicated that due to the effect of all the poisons studied changes developed early in catecholamine metabolism - the myocardial noradrenaline content decreased and the blood and urine monamine levels rose.

[Mechanism of decrease in noradrenaline content in the myocardium under the effect of various industrial poisons].

Alteration in content of catecholamines, DOPA and the monoaminooxidase activity (MAO) were observed in rat myocardium under prolonged administration of cobalt (5 mg of the metal per 1 kg of body weight). A correlation was observed between the decrease in noradrenaline content and the MAO activation. In myocardium content of noradrenaline was approximately constant in simultaneous administration of an MAO inhibitor nyalamide (20 mg/kg of body weight) and cobalt within 10 days.