Publications by authors named "Chee Wei Law"
Article Synopsis
- Colorectal cancer is a significant health issue, ranked as the third most common cancer globally and the second in Malaysia, with rising economic burdens anticipated due to trends and an aging population.
- This study involved an ambidirectional cohort at UMMC, focusing on Malaysian colorectal cancer patients from 2001 to 2010, aiming to assess 1-, 3-, and 5-year survival rates, compare ethnic survival rates, and identify survival predictors.
- Results showed a median survival of about 42 months for colorectal cancer and 5-year relative survival rates between 40.4% and 45.4%, with notable differences in outcomes among ethnic groups, particularly the Chinese who had the lowest 5
Background And Aims: Colorectal cancer is the second most frequent cancer in Malaysia. We aimed to assess the validity and reliability of the Malaysian Chinese version of European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire core (QLQ-C30) in patients with colorectal cancer.
Materials And Methods: Translated versions of the QLQ-C30 were obtained from the EORTC.
Psychometric Validation of the Bahasa Malaysia Version of the EORTC QLQ-CR29.
Asian Pac J Cancer Prev
October 2016
Background: This study examined the psychometric properties of the Bahasa Malaysia (BM) version of the European Organization for Research and Treatment of Cancer (EORTC) Colorectal Cancer-specific Quality Of Life Questionnaire (QLQ-CR29).
Materials And Methods: We studied 93 patients recruited from University Malaya and Universiti Kebangsaan Medical Centers, Kuala Lumpur, Malaysia using a self-administered method. Tools included QLQ-C30, QLQ-CR29 and Karnofsky Performance Scales (KPS).
Article Synopsis
- Colorectal cancer is the second most common cancer in Malaysia, with limited national data on treatment outcomes; this study analyzed 1,212 patients treated at the University Malaya Medical Centre over a decade.
- The patient population was predominantly Chinese, with an average age of 62 years, and significant differences were noted in cancer types among ethnic groups, especially with Malays presenting younger and more often with rectal cancer compared to Chinese and Indians.
- The findings suggest the need for targeted preventive measures based on ethnic and age-related disparities in colorectal cancer incidence.
Article Synopsis
- Recent research suggests microRNAs (miRNAs) could serve as important biomarkers in cancer, with this study focusing on miR-23a's role in colorectal cancer (CRC) development.
- Experiments showed that inhibiting miR-23a in CRC cell lines increased cell death and reduced cell survival, indicating its potential role in apoptosis resistance.
- The study also found an inverse relationship between miR-23a and APAF1 expression, proposing that targeting the miR-23a/APAF1 pathway could be useful for cancer treatment and prognosis.
Development of a risk score to stratify symptomatic adults referred for colonoscopy.
J Gastroenterol Hepatol
November 2014
Article Synopsis
- A new risk score model has been developed to help prioritize colonoscopy services for symptomatic patients, aiming to address the increasing demand on these services.
- Researchers studied 1,013 adults, finding significant rates of colonic neoplasia (17.3%) and colorectal cancer (11.3%) by analyzing various demographic and clinical factors.
- The model demonstrated good accuracy for identifying at-risk patients, but further studies are needed to validate its effectiveness in clinical settings.
Article Synopsis
- A study compared the outcomes and costs of two treatments—endoluminal clipping and surgery—for iatrogenic colonic perforations, with both methods used following complications from colonoscopies.
- Both treatments had similar success rates, but patients treated with endoscopic clipping had slightly shorter hospital stays and significantly lower healthcare costs, with median costs of $115.10 for clipping versus $1479.50 for surgery.
- The findings suggest that endoluminal clipping could be a more cost-effective option for managing these types of perforations, but the differences in hospitalization length were not statistically significant.
Background: MicroRNAs (miRNAs) are short, non-coding RNA molecules that act as regulators of gene expression. Circulating blood miRNAs offer great potential as cancer biomarkers. The objective of this study was to correlate the differential expression of miRNAs in tissue and blood in the identification of biomarkers for early detection of colorectal cancer (CRC).
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- Colorectal cancer is a significant public health issue in Malaysia, although it is one of the most treatable cancers, leading to many survivors who have varying health-related quality of life (HRQoL) outcomes.
- This study aimed to validate the Malaysian versions of EORTC quality of life instruments specifically for colorectal cancer patients across three major hospitals.
- Preliminary results indicate that the translated questionnaires are mostly understood by patients, with some challenges noted in the areas of overall quality of life and sexual health questions, suggesting the potential for good reliability and validity in measuring HRQoL.
Objective: Research over the past several decades has indicated that low socioeconomic class has a direct effect on health outcomes. In Malaysia, class distribution may differ with the region. The objective of this study was to compare the presentation and survival of colorectal cancer patients in two dissimilar cities, Kuala Lumpur and Kuching, Sarawak.
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