Enhanced isradipine sensitivity in vascular smooth muscle cells due to hypoxia-induced Ca1.2 splicing and RbFox1/Fox2 downregulation.

Calcium influx via the L-type voltage-gated Ca1.2 calcium channel in smooth muscle cells regulates vascular contraction. Calcium channel blockers (CCBs) are widely used to treat hypertension by inhibiting Ca1.

TRPM4 inhibition promotes angiogenesis after ischemic stroke.

Transient receptor potential melastatin 4 (TRPM4) is a voltage-dependent, nonselective cation channel. Under pathological conditions, sustained activation of TRPM4 leads to oncotic cell death. Here, we report the upregulation of TRPM4 in vascular endothelium following hypoxia/ischemia in vitro and in vivo.