Publications by authors named "Checkley W"

Intermediate care (IC) is prevalent nationwide, but little is known about how to best organize this level of care. Using a 99-item cross-sectional survey assessing four domains (hospital and physical IC features, provider and nurse staffing, monitoring, and interventions/services), we describe the organizational heterogeneity of IC within a five-hospital healthcare system. Surveys were completed by nurse managers from 12 (86%) of 14 IC settings.

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Intermediate care (IC) is prevalent nationwide, but little is known about how to best organize this level of care. Using a 99-item cross-sectional survey assessing four domains (hospital and physical IC features, provider and nurse staffing, monitoring, and interventions/services), we describe the organizational heterogeneity of IC within a five-hospital healthcare system. Surveys were completed by nurse managers from 12 (86%) of 14 IC settings.

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Repeated measurements of household air pollution may provide better estimates of average exposure but can add to costs and participant burden. In a randomized trial of gas versus biomass cookstoves in four countries, we took supplemental personal 24-h measurements on a 10% subsample for mothers and infants, interspersed between protocol samples. Mothers had up to five postrandomization protocol measurements over 16 months, while infants had three measurements over one year.

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Exposure to household air pollution has been linked to adverse health outcomes among women aged 40-79. Little is known about how shifting from biomass cooking to a cleaner fuel like liquefied petroleum gas (LPG) could impact exposures for this population. We report 24-h exposures to particulate matter (PM), black carbon (BC), and carbon monoxide (CO) among women aged 40 to <80 years participating in the Household Air Pollution Intervention Network trial.

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Background: Air pollution may impair child growth and cognitive development, with potential markers including birth length and head circumference.

Methods: The Household Air Pollution Intervention Network (HAPIN) trial was an open label multi-country-randomized controlled trial, with 3200 pregnant women aged 18-34 years (9-19 weeks of gestation) randomly assigned in a 1:1 ratio to receive liquefied petroleum gas (LPG) stove intervention compared to women continuing to cook with solid fuels for 18 months. Particulate matter ≤ 2.

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Multimorbidity data is typically analysed by tallying disease counts, which overlooks nuanced relationships among conditions. We identified clusters of multimorbidity and subpopulations with varying risks and examined their association with all-cause mortality using a data-driven approach. We analysed 8-year follow-up data of people ≥35 years who were part of the CRONICAS Cohort Study, a multisite cohort from Peru.

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Background: Hypertension is the leading modifiable risk factor for premature death globally despite the existence of evidence-based and cost-effective treatments. Medication nonadherence is cited as the main cause of treatment failure for hypertension. In Peru, adherence to anti-hypertensive medications of individuals with both hypertension and type 2 diabetes (T2D) is not well studied.

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Article Synopsis
  • - This study focuses on tackling hypertension in Peru through a hybrid research design testing a community health worker (CHW)-led program, aiming to improve blood pressure control within the national primary care system in Puno.
  • - A total of 1068 adults with hypertension will be recruited and randomly assigned to either usual care or a 12-month intervention, which includes home-based monitoring, medication support, and lifestyle counseling.
  • - The trial will evaluate clinical effectiveness (like changes in blood pressure) and implementation outcomes (such as program acceptance and cost-effectiveness), providing valuable insights for future health strategies in Peru and similar low- to middle-income countries (LMICs).
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Introduction: Hypertension and type 2 diabetes mellitus (T2DM) are two highly prevalent non-communicable diseases worldwide, both leading to disability and premature mortality in low-and-middle-income countries (LMICs). Nutritional interventions towards a healthier dietary pattern or food and nutrients intake have an important role on the management of this disease. This systematic review aims to evaluate the effect of nutritional interventions on the management of blood pressure and glycaemia in adults with hypertension and T2DM from LMICs.

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  • Household air pollution is a major environmental risk, especially in low- and middle-income countries, contributing to approximately 1.6 million premature deaths, prompting the HAPIN study to evaluate the impact of liquefied petroleum gas (LPG) stoves on health outcomes.
  • The study involved 800 pregnant women from Guatemala, India, Peru, and Rwanda, randomly assigning them to receive LPG stoves or continue using traditional biomass fuels, and monitored health indicators for 18 months.
  • The HAPIN Data Management Core effectively used the REDCap platform to collect and manage over 50 million data points, ensuring quality control and real-time data access, despite facing some logistical challenges.
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Traditional patient- and provider-level hypertension interventions have proven insufficient to halt hypertension as the leading cause of morbidity and mortality globally. Systems-level interventions are required to address factors challenging hypertension control across a social ecological framework, an under-studied topic particularly salient in low- and middle-income countries (LMICs) such as Peru. To inform such interventions, we sought to identify key health systems barriers to hypertension care in Puno, Peru.

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Background: More than 90% of the morbidity and mortality from chronic respiratory disease occurs in low-income and middle-income countries (LMICs), with substantial economic impact. Preserved ratio impaired spirometry (PRISm) is a prevalent lung function abnormality associated with increased mortality in high-income countries. We aimed to conduct a post-hoc analysis of a cross-sectional study to assess the prevalence of, the risk factors for, and the impact of PRISm in three diverse LMIC settings.

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Introduction: The presence of hypertension could reduce the health-related quality of life (HRQoL) of people with HIV (PWH). Yet, literature describing the HRQoL of PWH who have hypertension in Uganda is scarce making the design of locally adapted interventions cumbersome. In our study, we compared HRQoL scores of people with HIV with and without hypertension on long term antiretroviral therapy (ART) in Uganda.

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  • Brick kiln workers in Nepal are often overlooked and face high exposure to harmful silica, yet few use personal protective equipment (PPE) to safeguard their health.
  • A study conducted in Bhaktapur revealed that only 28.9% of surveyed workers used respiratory PPE, with many lacking awareness about silicosis and the effectiveness of proper protective gear.
  • Key factors influencing PPE use included higher household income and education levels, highlighting the need for improved education and resources to address knowledge gaps and encourage safety practices.
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  • Residential biomass burning significantly contributes to black carbon (BC) exposure in rural communities, especially among pregnant women in low- and middle-income countries.
  • In a study involving 3103 pregnant women, those who received liquefied petroleum gas stoves showed much lower BC exposure (2.8 μg/m) compared to those using traditional biomass stoves (9.6 μg/m).
  • The study identified primary stove type as the strongest predictor of BC exposure, and highlights the need to consider various factors, such as kitchen location and adherence to stove use, to improve the efficacy of cookstove intervention trials.
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Article Synopsis
  • - Brick kilns produce harmful emissions that negatively impact air quality and the health of nearby workers and residents, with limited evidence on the extent of these effects; a systematic review was conducted to analyze the pollution and its health consequences.
  • - Out of 104 studies reviewed, the majority were from South Asia, focusing on key pollutants like particulate matter (PM), sulfur dioxide (SO), and carbon monoxide (CO), with common health issues including respiratory problems and musculoskeletal disorders among brick kiln workers.
  • - The findings showed that traditional brick kilns emitted higher levels of PM and CO compared to improved designs, and while brick kiln workers generally had poorer health outcomes than unexposed individuals, the overall quality of the studies was low, indicating
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  • Approximately 3 billion people, mainly in low- and middle-income countries, use unclean fuels for everyday energy needs, leading to significant health issues like pneumonia and chronic lung disease.
  • A multidisciplinary group conducted a review of recent trials on clean cooking interventions to combat household air pollution (HAP) and reached 14 consensus recommendations for policy makers and practitioners.
  • While some interventions showed reduced exposure to HAP, there was no clear agreement on their effectiveness in improving health outcomes, highlighting the need for continued research and collaboration with policymakers.
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Background: Household air pollution might lead to fetal growth restriction during pregnancy. We aimed to investigate whether a liquefied petroleum gas (LPG) intervention to reduce personal exposures to household air pollution during pregnancy would alter fetal growth.

Methods: The Household Air Pollution Intervention Network (HAPIN) trial was an open-label randomised controlled trial conducted in ten resource-limited settings across Guatemala, India, Peru, and Rwanda.

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Introduction: Sarcopenia and sarcopenic obesity (SO) have emerged as significant contributors to negative health outcomes in the past decade. We aimed to estimate the prevalence of probable sarcopenia, sarcopenia, and SO in a community-dwelling population of 1151 adults aged ≥55 years in Lima, Peru.

Methods: This cross-sectional study was conducted between 2018 and 2020.

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Article Synopsis
  • Household air pollution (HAP) from solid fuel cooking is linked to negative pregnancy outcomes, and the HAPIN trial aimed to assess the effects of using LPG stoves in various countries like Guatemala, India, Peru, and Rwanda.
  • The study involved 3200 pregnant women who were either assigned to use LPG stoves or kept in a control group, with regular monitoring of fetal and neonatal outcomes as well as personal exposure to pollutants like particulate matter and carbon monoxide.
  • Results indicated that the LPG intervention didn't significantly lower risks of stillbirth, congenital anomalies, or neonatal mortality, nor did higher exposure levels to pollutants show a strong statistical association with these adverse outcomes.
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Purpose: Intensive care units (ICUs) in low- and middle-income countries have high mortality rates, and clinical data are needed to guide quality improvement (QI) efforts. This study utilizes data from a validated ICU registry specially developed for resource-limited settings to identify evidence-based QI priorities for ICUs in Ethiopia.

Materials And Methods: A retrospective cohort analysis of data from two tertiary referral hospital ICUs in Addis Ababa, Ethiopia from July 2021-June 2022 was conducted to describe casemix, complications and outcomes and identify features associated with ICU mortality.

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  • Household air pollution from biomass cooking fuels may contribute to stunted growth in infants, raising questions about whether switching to cleaner liquefied petroleum gas (LPG) can help reduce this risk.
  • A randomized trial with 3200 pregnant women in low- and middle-income countries was conducted, comparing the impact of using LPG cookstoves against traditional biomass cookstoves on infant growth at 12 months old.
  • Results showed that the intervention group using LPG had significantly lower exposure to fine particulate matter and a stunting rate of 27.4%, while the control group had a slightly higher stunting rate of 25.2%, indicating a potential benefit of switching to LPG.
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