Publications by authors named "Chebet K"

Objective: This article describes toxicities to antiretroviral therapy (ART) among HIV-infected patients receiving care at a clinic in a large urban slum in Nairobi, Kenya.

Methods: Patients were treated with nonnucleoside reverse transcriptase inhibitor-based ART and followed at scheduled intervals. Frequencies and cumulative probabilities of toxicities were calculated.

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Article Synopsis
  • The study focused on assessing how well patients in a resource-limited area of Nairobi, Kenya, were able to stick with antiretroviral therapy (ART) and respond to it.
  • Results showed significant improvement in patients' immune health after one year of ART, with 74% of those monitored achieving a viral load below 400 copies/mL.
  • The majority of patients (84%) continued to receive care over the follow-up period, demonstrating that effective ART programs can succeed even in difficult circumstances with adequate support and community engagement.
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  • The study aimed to assess the impact of an STD syndromic management program introduced in 1995 on the patterns of STD syndromes from 1990 to 2001.
  • A significant decrease in genital ulcer disease (GUD), urethral discharge (UD), and vaginal discharge (VD) was observed from baseline levels in the years leading up to 2000, with declines noted across various demographics.
  • However, after free STD medication ended in 2001, the proportions of these syndromes started to rise again, suggesting a connection between the management program's implementation and the later increase in STD cases.
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Article Synopsis
  • Studies in sub-Saharan Africa show that HIV prevalence is significantly higher in young women compared to young men, especially among those aged 15-24 years.
  • Data from Kenya's HIV sentinel surveillance (1990-2001) indicates an increase in HIV prevalence among STD patients, with women in the younger age group being nearly twice as likely to be infected as their male counterparts.
  • Unmarried women also face a higher HIV risk compared to men, and this trend remains consistent across various factors, stressing the need for targeted interventions for adolescent women showing STD symptoms.
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Dramatic price reductions make antiretroviral drugs increasingly affordable in Africa. However, poor infrastructure, conflicting interests, and lack of commitment to a common strategy could keep them beyond the reach of most infected people. Recent experiences in Kenya, where the political will exists, show the complexity of turning this opportunity into safe and effective practice.

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