A phase II double-blind multicentre, placebo-controlled trial to assess the efficacy and safety of alpelisib (BYL719) in paediatric and adult patients with Megalencephaly-CApillary malformation Polymicrogyria syndrome (MCAP): the SESAM study protocol.

Introduction: The megalencephaly capillary malformation polymicrogyria (MCAP syndrome) results from mosaic gain-of-function variants. The main clinical features are macrocephaly, somatic overgrowth, neurodevelopmental delay and brain anomalies. Alpelisib (Vijoice) is a recently FDA-approved PI3Kα-specific inhibitor for patients with PIK3CA-related overgrowth spectrum (PROS).

Agricultural waste-based biochars for sustainable removal of heavy metals from stabilized landfill leachate.

In this work, biochars were used as adsorbents to remove Cu, Cd, and Zn ions in a real stabilized leachate from a controlled landfill. Oak fruit shells biochar (OFSBC) and date palm fibers biochar (DPFBC) were obtained by pyrolysis of oak fruit shells and date palm fibers at 700 °C and 400 °C, respectively. OFSBC and DPFBC showed well-developed structures and high specific surface areas (520.

Epidemiology and management of heart failure with reduced ejection fraction in a Tunisian university hospital.

Introduction: Despite considerable advances in treatment, heart failure (HF) remains a serious public health problem linked to a high rate of mortality. The aim of this work was to describe the epidemiological, clinical and evolutionary features of HF in a Tunisian university hospital.

Methods: This was a retrospective study including 350 hospitalised patients diagnosed with HF with reduced ejection fraction (≤ 40%) during the period between 2013 and 2017.

KI and TEDA influences towards the retention of radiotoxic CHI by activated carbons.

Activated carbons (AC) are widely used within the ventilation networks of nuclear facilities to trap volatile iodine species. In this paper, the performances of various commercial activated carbons towards the trapping of γ-labelled methyl iodide were evaluated in semi-pilot scale under different R.H.

Structure-Activity Relationships between the State of Silver on Different Supports and Their I and CHI Adsorption Properties.

In this study, the performances of silver-impregnated adsorbents prepared from different host supports (SBA-15, alumina, ceria, and faujasite Y zeolite) and calcined or not at 500 °C (1 h) were compared for the capture of I and CHI. By keeping the silver content rather similar (about 15-17 wt %) among the sorbents, it was possible to assess the effect of silver dispersion and speciation on the adsorption capacities measured for both adsorbates. In a first part, several characterization techniques (XRD, DRS-UV-Vis, TEM, etc.

Characterization of a Sex-Determining Region and Its Genomic Context via Statistical Estimates of Haplotype Frequencies in Daughters and Sons Sequenced in Pools.

Sex chromosomes are generally derived from a pair of autosomes that have acquired a locus controlling sex. Sex chromosomes may evolve reduced recombination around this locus and undergo a long process of molecular divergence. At that point, the original loci controlling sex may be difficult to pinpoint.

Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity.

To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs' functions according to body mass index (BMI) categories. High-dimensional flow cytometric characterization of immune cell subsets was performed at admission, 30 systemic cytokines/chemokines levels were sequentially measured, thirteen endothelial markers were determined at admission and at the zenith of the cytokines. Computed tomography scans on admission were quantified for lung damage and hepatic steatosis (n = 23).

No difference in HIV-1 integrase inhibitor resistance between CSF and blood compartments.

Background: Little is known about HIV-1 integrase inhibitor resistance in the CNS.

Objectives: This study aimed to evaluate integrase inhibitor resistance in CSF, as a marker of the CNS, and compare it with the resistance in plasma.

Methods: HIV integrase was sequenced both in plasma and CSF for 59 HIV-1 patients.

Chromosomal scale assembly of parasitic wasp genome reveals symbiotic virus colonization.

Endogenous viruses form an important proportion of eukaryote genomes and a source of novel functions. How large DNA viruses integrated into a genome evolve when they confer a benefit to their host, however, remains unknown. Bracoviruses are essential for the parasitism success of parasitoid wasps, into whose genomes they integrated ~103 million years ago.

Effects of water vapour and temperature on the retention of radiotoxic CHI by silver faujasite zeolites.

In this work, Ag/X and Ag/Y faujasite zeolites were evaluated as candidate sorbents for the retention of methyl iodide under conditions close to those expected in a severe nuclear accident. Different categories of tests were conducted from laboratory to semi-pilot scales. First, the effects of temperature and water vapour on the CHI retention/decomposition mechanism were investigated under lab-scale conditions.

Comparative Genomics of Strictly Vertically Transmitted, Feminizing Microsporidia Endosymbionts of Amphipod Crustaceans.

Microsporidia are obligate intracellular eukaryotic parasites of vertebrates and invertebrates. Microsporidia are usually pathogenic and undergo horizontal transmission or a mix of horizontal and vertical transmission. However, cases of nonpathogenic microsporidia, strictly vertically transmitted from mother to offspring, have been reported in amphipod crustaceans.

Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products.

For several years, environmental exogenous agents, called endocrine disruptors, are suspected to interfere with the essential functions of reproduction and development in many living organisms. In this study, endocrine disruptors including five phthalates and two bisphenols contents in finished products were assayed and their estrogenic activity were measured by using the Yeast Estrogen Screen system with respect to human and trout estrogen receptors hERα and rtER. Independently of the estrogen receptor, only short-chain phthalates (DBP and BBP) and the two bisphenols exhibited an estrogenic activity.

AuNP Pyrazolo[3,4-]pyrimidine Nanosystem in Combination with Radiotherapy against Glioblastoma.

Gold-nanoparticle (AuNP)-conjugated drugs represent a promising and innovative antitumor therapeutic approach. In our study, we describe the design, the synthesis, the preparation, and the characterization of AuNPs conjugated with the pyrazolo[3,4-]pyrimidine derivative SI306, a c-Src inhibitor. AuNPs-SI306 showed a good loading efficacy (65%), optimal stability in polar media and in human plasma, and a suitable morphological profile: a ζ-potential of -43.

Sex chromosomes control vertical transmission of feminizing Wolbachia symbionts in an isopod.

Microbial endosymbiosis is widespread in animals, with major ecological and evolutionary implications. Successful symbiosis relies on efficient vertical transmission through host generations. However, when symbionts negatively affect host fitness, hosts are expected to evolve suppression of symbiont effects or transmission.

Echocardiographic characteristics of cardiac involvement in Systemic lupus erythematosus.

Introduction: Echocardiography is a non invasive tool for the assessment of systemic lupus erythematesus (SLE) involvement .

Aim Of Study: to investigate the cardiac involvement in patients diagnosed with SLE assessed by echocardiography and to study relationship between several factors and cardiac manifestation .

Methods: retrospective study of 76 patients with diagnosis of SLE between 2008 and 2017.

The Genome of Armadillidium vulgare (Crustacea, Isopoda) Provides Insights into Sex Chromosome Evolution in the Context of Cytoplasmic Sex Determination.

The terrestrial isopod Armadillidium vulgare is an original model to study the evolution of sex determination and symbiosis in animals. Its sex can be determined by ZW sex chromosomes, or by feminizing Wolbachia bacterial endosymbionts. Here, we report the sequence and analysis of the ZW female genome of A.

Reactivity of pyrazole derivatives with halomethanes: A DFT theoretical study.

The N-alkylation reaction of pyrazole derivatives with halomethanes was studied using density functional theory (DFT). The hybrid method B3LYP was employed, along with an ECP basis set such as LANL2DZ for halogen atoms (X = Cl, Br, I) and the 6-311 + G(d,p) basis set for all other atoms. In order to predict the specific site at which the pyrazole derivatives interact with halomethanes, local reactivity descriptors such as the Fukui functions were calculated.

Prosthetic valve endocarditis: clinical, bacteriological and therapeutic aspects.

Background: The prosthetic valve endocarditis(PVE) is a serious complication of valve replacement surgery. The aim of this work was to analyze the clinical and echocardiography characters of the PVE, deduce surgery indication, and determinate the prognostic factors Methods :We presented a retrospective descriptive study from 2000 to 2014 which included 30 patients hospitalized in department of cardiology in la Rabta hospital for certain PVE according to DUCKES criteria.

Results: Our study consisted of 18 male patients with sex ratio of 1.

Evaluation of Silver Zeolites Sorbents Toward Their Ability to Promote Stable CHI Storage as AgI Precipitates.

In this study, up to 13 different silver zeolites sorbents were prepared by repeated ion exchange from their parent structures (FAU X and Y, MOR, *BEA, MFI, FER), characterized, and evaluated for their ability to capture methyl iodide in the context of a nuclear severe accident. A novel methodology was implemented to establish structure-activity relationships between sorbent properties and iodine trapping stability. After saturation of the zeolite bed with CHI during a dynamic breakthrough experiment at 100 °C, a two-step quantitative desorption method was elaborated with the aim to quantify separately the CHI fractions trapped by physisorption, chemisorption, or reacted as AgI precipitates.