Chemical Composition, Free Radicals and Pathogenic Microbes in the Extract Derived from : In Silico and In Vitro Approaches.

Marine algae are renowned for their health benefits due to the presence of functional bioactive compounds. In this context, this study aims to valorize the extract of a seaweed, (), through phytochemical characterization using liquid chromatography-mass spectrometry (HPLC-MS), as well as in vitro and in silico evaluation of its biological activities (antioxidant and antimicrobial). Phytochemical characterization revealed that the ethanolic extract of (DdEx) is rich in phenolic compounds, with a total of 22 phycocompounds identified.

Antioxidant potential, antimicrobial activity, polyphenol profile analysis, and cytotoxicity against breast cancer cell lines of hydro-ethanolic extracts of leaves of ( L.) from Eastern Morocco.

Introduction: Many beneficial compounds found in fig leaves can be used in tea and medicine. These compounds aid with digestion, reduce inflammation, and treat diabetes and bronchitis. Chetoui, Malha, Ghoudane, and Onk Hmam fig leaf hydro-ethanol extracts from Eastern Morocco were analyzed for metabolites and biological activities.

A Study of the Bioactive Compounds, Antioxidant Capabilities, Antibacterial Effectiveness, and Cytotoxic Effects on Breast Cancer Cell Lines Using an Ethanolic Extract from the Aerial Parts of the Indigenous Plant Coss. & Moq.

contain numerous bioactive compounds that provide several advantages, including antioxidant, antibacterial, anticancer, neuroprotective, anti-inflammatory, and antidiabetic characteristics. This study aimed to make a hydroethanolic extract from the aerial part of the plant, analyze its biochemical compounds, and test its biological activities. From HPLC-DAD analysis, cinnamic acid, sinapic acid, and vanillin bioactives were found to be the main compounds in the extract.

Unraveling the hepatoprotective and anti-pancreatic cancer potential of : a comprehensive and in silico evidence.

Guss. () is a medicinal plant used for cancer treatment. However, these treatments may be associated with complications that need to be investigated.

Salsoline derivatives, genistein, semisynthetic derivative of kojic acid, and naringenin as inhibitors of A42R profilin-like protein of monkeypox virus: studies.

Monkeypox virus (MPV) infection has developed into a re-emerging disease, and despite the potential of tecovirimat and cidofovir drugs, there is currently no conclusive treatment. The treatment's effectiveness and cost challenges motivate us to use approaches to seek natural compounds as candidate antiviral inhibitors. Using Maestro 11.

Antifungal, Insecticidal, and Repellent Activities of Essential Oil and Molecular Docking of Its Constituents against Acetylcholinesterase and -Tubulin.

The aim of this study was to determine the phytochemical composition and evaluate the antifungal and insecticidal properties of essential oil (EO). GC-MS was employed to analyze the phytochemical profile of the EO. The antifungal activity of the EO was assessed by calculating growth inhibition rates for , , and .

The chemical composition and the preservative, antimicrobial, and antioxidant effects of Boiss. essential oil: an and approach.

Introduction: The aim of this study was to evaluate the antioxidant, antimicrobial, and preservative efficacy of Boiss. essential oil (EO) in a topically applied formulation using a challenge test.

Methods: The essential oil was extracted from the aerial part of using hydrodistillation, and the obtained EO was further analyzed by gas chromatography/mass spectrometry (GC/MS).

Phenolic Composition of Jacq. Extract and Its Anti-Inflammatory, Hepatoprotective, and Antileukemia Effects.

() is a prominent plant used in Moroccan traditional medicine. This study investigated the phenolic composition and the anti-inflammatory, the hepatoprotective, and the anticancer activities of a hydroethanolic extract of leaves and stems. Ultra-high-performance liquid chromatography identified the phenolic profile.

and studies of the effects of oil extracted from L. seeds on healing of burned skin wounds in rats.

Introduction: This study investigates the potential effects of cannabis seed oil (CSO) on the wound healing process. The aim was to assess the efficacy of CSO in treating skin wounds using an animal model and to explore its anti-inflammatory properties through in silico analysis.

Methods: Eighteen male albino Wistar rats, weighing between 200 and 250 g, were divided into three groups: an untreated negative control group, a group treated with the reference drug silver sulfadiazine (SSD) (0.

Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of L.

This study aims to assess the chemical composition of the aqueous extract of L. leaves, as well as the potential of aqueous and hydroethanol extracts of the leaves and seeds as analgesic, anti--inflammatory, and antioxidant agents. The contents of phenolics and inorganic constituents were determined in seeds and leaves; antioxidant capacity was assessed by 3 complementary and diverse tests.

Origanum majorana L. polyphenols: antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor.

Epilepsy is a chronic brain disease characterized by repeated seizures and caused by excessive glutamate receptor activation. Many plants are traditionally used in the treatment of this disease. This study aimed to evaluate the bioavailability of a polyphenolic extract obtained from L.

Analyzing the Bioactive Properties and Volatile Profiles Characteristics of Opuntia dillenii (Ker Gawl.) Haw: Exploring its Potential for Pharmacological Applications.

In this investigation, the study focused on the chemical constitution and the antioxidative as well as anti-inflammatory characteristics of oils and pulpy variants (Imatchan (IM), Harmocha (HA), and Aknari (AK)) sourced from O. dillenii. This inquiry encompassed both in vitro and in silico analyses.

Antioxidant, Antimicrobial, and Insecticidal Properties of Chemically Characterized Essential Oils Extracted from : In Vitro and In Silico Analysis.

The present study aimed to explore the phytochemical profile, and evaluate the antioxidant, antimicrobial, and insecticidal properties, of Moroccan L. essential oil (ML-EO) using in vitro and in silico assays. Noteworthily, as chromatography (GC-MS/MS) revealed that ML-EO is majorly composed of piperitenone oxide (53.

Pharmacological activities of chemically characterized essential oils from (Forssk.).

The present work aimed at characterizing the phytochemical composition of essential oil (HTEO), assessing its antifungal activity against various fungal strains, evaluating its insecticidal and repulsive properties against , and determine its antioxidant capacity. To this end, Gas chromatography-mass spectrometry analysis detected 34 compounds in HTEO, with -Caryophyllene being the major constituent (36.94%).

Study of the Phytochemical Composition, Antioxidant Properties, and In Vitro Anti-Diabetic Efficacy of Extracts.

In this study, a comparison was made of the chemical makeup of different extracts obtained from , a type of red seaweed that was gathered from the Nador lagoon situated in the northern part of Morocco. Additionally, their anti-diabetic and antioxidant properties were investigated. The application of GC-MS technology to analyze the fatty acid content of the samples revealed that linoleic acid and eicosenoic acid were the most abundant unsaturated fatty acids across all samples, with palmitic acid and oleic acid following in frequency.

Quercetin and Ferulic Acid Elicit Estrogenic Activities In Vivo and In Silico.

In this study, we examined the sub-acute toxicity of quercetin and ferulic acid and evaluated their effects on protein, cholesterol, and estrogen levels in vivo. Six groups of female Wistar rats were fed by gavage. The first and second groups represent the positive (Clomiphene citrate 10 mg/kg) and negative (NaCl 0.

Extracts of (Delile) Vis Exhibit In Vivo Wound Healing, Anti-Inflammatory and Analgesic Activities, and Other In Vitro Therapeutic Effects.

The plant (Delile) () has many uses in traditional pharmacology. Aqueous (BCAE) and ethanolic extracts (BCEE) obtained from the aerial parts can be used as an alternative to some synthetic drugs. In vitro, DPPH, FRAP and TAC are three tests used to measure antioxidant efficacy.

Phenolic Composition, Wound Healing, Antinociceptive, and Anticancer Effects of Extracts.

(Guss.) is an important medicinal plant widely used in Morocco for various traditional purposes. Our work aimed to evaluate the phenolic composition, wound healing, antinociceptive, and anticancer activities of extracts.

The LC-MS/MS Identification and Analgesic and Wound Healing Activities of Chaix: In Vivo and In Silico Approaches.

We earlier emphasized in vivo the lavender plant's ( Chaix.) anti-inflammatory and estrogenic activities and described the chemical compositions of its hydro-ethanolic (HE) extract. We used LC-MS/MS and GC-MS analyses to profile the phytochemical composition of the HE extract and to assess the analgesic and wound-healing effects of both the hydro-ethanolic (HE) and polyphenolic (LOP) extracts in vivo and in silico.

Apoptosis-mediated anti-proliferative activity of against human breast cancer cells, and molecular docking of its major polyphenolics to Caspase-3.

Due to poor diagnosis breast cancer in women has emerged as the most common cause of death disease in developing countries. Medicinal plants have been used for thousands of years and can be useful in healthcare, especially in developing countries. Ethanol extracts of leaves of fire bush or arta ( EECC), exhibited significant anticancer potencies against two breast cancer cell lines, MCF-7 and MDA 231.