Downregulation of VEGFR2 signaling by cedrol abrogates VEGF‑driven angiogenesis and proliferation of glioblastoma cells through AKT/P70S6K and MAPK/ERK1/2 pathways.

Cedrol is a sesquiterpene alcohol isolated from , which has been traditionally used in aromatherapy and has anticancer, antibacterial and antihyperalgesic effects. One characteristic of glioblastoma (GB) is the overexpression of vascular endothelial growth factor (VEGF), which induces a high degree of angiogenesis. Although previous studies have reported that cedrol inhibits GB growth by inducing DNA damage, cell cycle arrest and apoptosis, its role in angiogenesis remains unclear.

Mortality Evaluation and Life Expectancy Prediction of Patients with Hepatocellular Carcinoma with Data Mining.

Background: The complexity of systemic variables and comorbidities makes it difficult to determine the best treatment for patients with hepatocellular carcinoma (HCC). It is impossible to perform a multidimensional evaluation of every patient, but the development of guidelines based on analyses of said complexities would be the next best option. Whereas conventional statistics are often inadequate for developing multivariate predictive models, data mining has proven more capable.

Demonstration of distributed collaborative learning with end-to-end QoT estimation in multi-domain elastic optical networks.

This paper proposes a distributed collaborative learning approach for cognitive and autonomous multi-domain elastic optical networking (EON). The proposed approach exploits a knowledge-defined networking framework which leverages a broker plane to coordinate the operations of multiple EON domains and applies machine learning (ML) to support autonomous and cognitive inter-domain service provisioning. By employing multiple distributed ML blocks learning domain-level features and working with broker plane aggregation ML blocks (through the chain rule-based training), the proposed approach enables to develop cognitive networking applications that can fully exploit the multi-domain EON states while obviating the need for the raw and confidential intra-domain data.

Seeing pressure in color based on integration of highly sensitive pressure sensor and emission tunable light emitting diode.

We demonstrate a highly sensitive, low-cost, environmental-friendly pressure sensor derived from a wool-based pressure sensor with wide pressure sensing range using wool bricks embedded with a Ag nano-wires. The easy fabrication and light weight allow portable and wearable device applications. Wth the integration of a light-emitting diode possessing multi-wavelength emission, we illustrate a hybrid multi-functional LED-integrated pressure sensor that is able to convert different applied pressures to light emission with different wavelengths.

Study on Tripping Risks in Fast Walking through Cadence-Controlled Gait Analysis.

Fast walking is a common exercise for most people to promote health. However, a higher cadence due to fast walking on ordinary or uneven ground raises the risk of tripping. To investigate the tripping issue, research to observe the gait in fast walking is needed.

Collective Lasing Behavior of Monolithic GaN-InGaN Core-Shell Nanorod Lattice under Room Temperature.

We demonstrated a monolithic GaN-InGaN core-shell nanorod lattice lasing under room temperature. The threshold pumping density was as low as 140 kW/cm with a quality factor as high as 1940. The narrow mode spacing between lasing peaks suggested a strong coupling between adjacent whisper gallery modes (WGM), which was confirmed with the far-field patterns.

Color-conversion efficiency enhancement of quantum dots via selective area nano-rods light-emitting diodes.

A large enhancement of color-conversion efficiency of colloidal quantum dots in light-emitting diodes (LEDs) with novel structures of nanorods embedded in microholes has been demonstrated. Via the integration of nano-imprint and photolithography technologies, nanorods structures can be fabricated at specific locations, generating functional nanostructured LEDs for high-efficiency performance. With the novel structured LED, the color-conversion efficiency of the existing quantum dots can be enhanced by up to 32.

Bridging the "green gap" of LEDs: giant light output enhancement and directional control of LEDs via embedded nano-void photonic crystals.

Green LEDs do not show the same level of performance as their blue and red cousins, greatly hindering the solid-state lighting development, which is the so-called "green gap". In this work, nano-void photonic crystals (NVPCs) were fabricated to embed within the GaN/InGaN green LEDs by using epitaxial lateral overgrowth (ELO) and nano-sphere lithography techniques. The NVPCs act as an efficient scattering back-reflector to outcouple the guided and downward photons, which not only boost the light extraction efficiency of LEDs with an enhancement of 78% but also collimate the view angle of LEDs from 131.

GaN Micromechanical Resonators with Meshed Metal Bottom Electrode.

This work describes a novel architecture to realize high-performance gallium nitride (GaN) bulk acoustic wave (BAW) resonators. The method is based on the growth of a thick GaN layer on a metal electrode grid. The fabrication process starts with the growth of a thin GaN buffer layer on a Si (111) substrate.

Synthesis and characterization of two-photon chromophores based on a tetrasubstituted tetraethynylethylene scaffold.

A new series of model dye molecules composed of three multibranched analogues based on the tetrasubstituted tetraethynylethylene structural motif have been synthesized and experimentally shown to possess strong and widely dispersed two-photon absorption (2PA) in the near-IR region. It was found that the spectral position of the major 2PA band could be tuned by the electronic nature of the selected substitution units. The studied model fluorophores also exhibited fairly low photodegradation of their fluorescence intensity even under prolonged UV-light irradiation, which is beneficial for the development of fluorescence probes that are needed for long-term light exposure.

Improvement of emission uniformity by using micro-cone patterned PDMS film.

Micro-patterned PDMS film was fabricated and combined with LED chip on board (COB) package to improve the emission uniformity of LED chip. The micro scale patterned sapphire substrate (PSS) was used as a mold to fabricate micro-cone patterned PDMS (MC-PDMS) film. A strong scattering effect from this MC-PDMS film can be verified by the high haze ratio and the Bi-directional Transmission effect.

Degenerate two-photon absorption and effective optical-power-limiting properties of multipolar chromophores derived from 2,3,8-trisubstituted indenoquinoxaline.

Two analogous multipolar chromophores (1 and 2) that contained 2,3,8-trisubstituted indenoquinoxaline moieties have been synthesized and characterized for their two-photon absorption properties, both in the femtosecond and nanosecond time regimes. We demonstrated that their multi-branched framework structures, which incorporated appropriately functionalized indenoquinoxaline units, afforded large molecular nonlinear absorptivities within the studied spectroscopic range. Effective optical-power-limiting and stabilization behaviors in the nanosecond regime of dye molecule (2) were also investigated and the results indicated that such a structural motif could be a useful approach to the molecular design of highly active two-photon systems for quick-response and related broadband optical-suppressing applications, in particular for confronting laser pulses of a long duration.

Synthesis and two-photon absorption property characterizations of small dendritic chromophores containing functionalized quinoxaliniod heterocycles.

A series of star-shaped multi-polar chromophores (compounds 1-3) containing functionalized quinoxaline and quinoxalinoid (indenoquinoxaline and pyridopyrazine) units has been synthesized and characterized for their two-photon absorption (2PA) properties both in the femtosecond and the nanosecond time domain. Under our experimental conditions, these model fluorophores are found to manifest strong and wide-dispersed two-photon absorption in the near-infrared region. It is demonstrated that molecular structures with multi-branched π frameworks incorporating properly functionalized quinoxalinoid units would possess large molecular nonlinear absorptivities within the studied spectral range.

High efficiency GaN-based light-emitting diodes with embedded air voids/SiO2 nanomasks.

In this paper, the high performance GaN-based light-emitting diodes (LEDs) with embedded microscale air voids and an SiO(2) nanomask by metal-organic chemical vapor deposition (MOCVD) were demonstrated. Microscale air voids and an SiO(2) nanomask were clearly observed at the interface between GaN nanorods (NRs) and the overgrown GaN layer by scanning electron microscopy (SEM). From the reflectance spectra we show strong reflectance differences due to the different refractive index gradient between the GaN grown on the nanotemplate and sapphire.

Neuromodulation on cervical spinal cord combined with hyperbaric oxygen in comatose patients--a preliminary report.

Background: Because both SCS and HBO therapy have shown some promise in treating patients with states of reduced consciousness, we evaluated the combination of therapies in a prospective trial in comatose patients.

Methods: Twelve patients who had received median nerve stimulation for 3 months without improvement in consciousness received cSCS for 1 year combined with simultaneous HBO therapy for the first 3 months. Another group enrolled 12 patients who received median nerve stimulation only were served as control.

Change in cerebral perfusion of patients with coma after treatment with right median nerve stimulation and hyperbaric oxygen.

Background.  Survival rates after acute brain injury have improved, but persistent coma continues to be a major clinical problem. Objective.