Publications by authors named "Che-Hao Tsao"
Development of an In Vitro 3D Model for Investigating Ligamentum Flavum Hypertrophy.
Biol Proced Online
September 2020
Article Synopsis
- Ligamentum flavum hypertrophy (LFH) is a key contributor to degenerative lumbar spinal stenosis, leading to various painful conditions, but its exact causes are still not well understood.
- Researchers created three-dimensional LF spheroid cultures from primary LFH tissue, which better mimic the in vivo environment compared to traditional two-dimensional cultures.
- The study found that these 3D spheroids maintained cell viability and characteristics similar to natural LF hypertrophic tissue, highlighting their potential for future research into LFH pathogenesis.