Publications by authors named "Che Sheng Chu"

Despite the generally good prognosis of differentiated thyroid cancer (DTC), impairments in health-related quality of life (HRQoL) remain a major concern in these patients. This study examined the patterns and predictors of change in mental and physical HRQoL in DTC survivors following radiotherapy ablation. Two hundred patients with DTC who received radiotherapy ablation in southern Taiwan between 2015 and 2018 were interviewed using the Taiwan version of the 36-item Short-form Health Survey (SF-36), the Taiwanese Depression Questionnaire (TDQ), and the Hamilton Rating Scale for Anxiety (HAM-A) at baseline and after 24 and 48 weeks of treatment.

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Background: Compared to functional magnetic resonance imaging (fMRI), source localization of a scalp-recorded electroencephalogram (EEG) provides higher temporal resolution and frequency synchronization to better understand the potential neurophysiological origins of disrupted functional connectivity (FC) in major depressive disorder (MDD). The present study aimed to investigate EEG-sourced measures to examine the FC in drug-free patients with MDD.

Method: Resting-state 32-channel EEG were recorded in 84 drug-free patients with MDD and 143 healthy controls, and the cortical source signals were estimated.

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Article Synopsis
  • - The study explored the link between various types of cancers and the risk of developing dementia, focusing on cancer survivors compared to a control group.
  • - Researchers analyzed data from over 32,000 cancer patients and found that these survivors had a significantly increased risk of developing Alzheimer's disease, unspecified dementia, and other forms of dementia, especially those with digestive and genitourinary cancers.
  • - The findings suggest that certain cancers increase the likelihood of dementia, indicating a need for further research into the mechanisms behind this association.
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Objective: We aimed to examine the factors associated with treatment outcomes in patients with Alzheimer's disease (AD) after 1 year of acetylcholinesterase inhibitors (AChEI) treatment.

Method: We obtained electronic medical records from a medical center in Southern Taiwan between January 2015 and September 2021. Participants aged ≥60 who were newly diagnosed with AD and had been prescribed AChEIs were included.

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Ochratoxin A (OTA) is a type of mycotoxin commonly found in raw and processed foods. It is essential to be aware of this toxin, as it can harm your health if consumed in high quantities. OTA can induce toxic effects in various cell models.

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Introduction: Cranial electrotherapy stimulation (CES) is beneficial in reducing anxiety in psychiatric patients. However, no studies have reported on elderly patients with generalized anxiety disorders (GAD). This study aimed to determine the efficacy and safety of a 6-week CES intervention for late-life GAD.

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Aim: Large language models (LLMs) have been suggested to play a role in medical education and medical practice. However, the potential of their application in the psychiatric domain has not been well-studied.

Method: In the first step, we compared the performance of ChatGPT GPT-4, Bard, and Llama-2 in the 2022 Taiwan Psychiatric Licensing Examination conducted in traditional Mandarin.

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Aim: This study aimed to examine dose-effects of total pulses on improvement of depressive symptoms in patients with treatment-resistant depression (TRD) receiving repetitive transcranial magnetic stimulation (rTMS) over the left dorsal lateral prefrontal cortex (DLPFC).

Materials And Methods: The MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, PsycINFO, and ClinicalTrial.gov databases were systematically searched.

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Non-invasive brain stimulation (NIBS) is a promising treatment for bipolar depression. We systematically searched for randomized controlled trials on NIBS for treating bipolar depression (INPLASY No: 202340019). Eighteen articles (N = 617) were eligible for network meta-analysis.

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Comorbid obsessive-compulsive disorder (OCD) is common among patients with schizophrenia. The role of electroconvulsive therapy (ECT) in the treatment of OCD in schizophrenia is unclear. Herein, we present a 45-year-old man who was diagnosed with schizophrenia along with OCD and received ECT due to relapse of psychosis owing to refractive schizophrenia.

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Objective: Individuals with dementia are at a substantially elevated risk for mortality; however, few studies have examined multimorbidity patterns and determined the inter-relationship between these comorbidities in predicting mortality risk.

Methods: This is a prospective cohort study. Data from 6,556 patients who were diagnosed with dementia between 1997 and 2012 using the Taiwan National Health Insurance Research Database were analyzed.

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Objective: Menopausal symptoms are common in midlife women and have broad impacts on their daily functioning and quality of life. Black cohosh extracts have been widely used to relieve menopausal symptoms. However, the comparative benefits of different combined black cohosh regimens remain inconclusive.

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Background: Early identification of different stages of cognitive impairment is important to provide available intervention and timely care for the elderly.

Objective: This study aimed to examine the ability of the artificial intelligence (AI) technology to distinguish participants with mild cognitive impairment (MCI) from those with mild to moderate dementia based on automated video analysis.

Methods: A total of 95 participants were recruited (MCI, 41; mild to moderate dementia, 54).

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Background: To investigate the association between exposure to antidepressants (ADs) and the risk of epilepsy among patients exposed to ADs.

Method: We conducted a case-control study using Taiwan's National Health Insurance Research Database between 1998 and 2013. A total of 863 patients with epilepsy and 3,452 controls were included.

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There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID.

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Article Synopsis
  • Dementia, especially Alzheimer's disease, really affects how people think and live, and current medications don't do enough to help.
  • A study looked at noninvasive brain stimulation (NIBS) methods, which are new ways to help improve thinking skills in people with Alzheimer's through special electrical stimulation.
  • The results showed that a specific type of NIBS called tDCS seems to help improve thinking abilities without causing many side effects, but more studies are needed to be sure.
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Article Synopsis
  • The COVID-19 pandemic prompted strict quarantine and isolation measures globally, but compliance varied among individuals, possibly influenced by personality traits such as openness and optimism.
  • An online survey conducted in April-May 2020 gathered responses from 7,404 participants, mainly from Poland and Italy, assessing their personality traits and adherence to lockdown rules.
  • The study found key factors influencing stricter compliance included temporary work suspension, perceived financial difficulty, and junior high school education, while self-assessed personality traits had a minimal impact on adherence.
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Objective: To integrate all evidence derived from randomized controlled trials (RCTs) of both pharmacological and nonpharmacological augmentation interventions for clozapine-resistant schizophrenia (CRS).

Methods: Six major electronic databases were systematically searched for RCTs published until July 10, 2021. The primary outcome was change in overall symptoms, and the secondary outcomes were positive and negative symptoms and acceptability.

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Introduction: Evidence has suggested an association between bacterial infection and increased risk of subsequent major mental disorders (MMDs). Whether such association varies with different pathogens remains unclear. We aimed to investigate the risk of subsequent MMDs after exposure to bacterial pathogens in children and adolescents.

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Background: Irritable bowel syndrome (IBS) was found in 11% of the general population worldwide. The current pharmacologic management of IBS was unsatisfactory, and it was accompanied by a number of adverse events. Melatonin was found to play an important role in gastrointestinal smooth muscle motility.

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Article Synopsis
  • A study was conducted to compare mortality rates between individuals with different types of dementia and those without dementia to help inform preventive measures for at-risk populations.
  • The researchers carried out a systematic review and meta-analysis of 78 studies, analyzing data on over 63,000 individuals with dementia and more than 152,000 controls.
  • Findings indicated that individuals with dementia had significantly higher mortality rates compared to those without dementia, with a hazard ratio suggesting they were about 5.9 times more likely to die during the study period.
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Aims: Previous studies have suggested an increased risk of developing schizophrenia later in life in children with autism spectrum disorder (ASD). This study aims to investigate the diagnosis stability and the potential predictors for progression to schizophrenia in ASD.

Methods: We recruited 11 170 adolescents (10-19 years) and young adults (20-29 years) with ASD between 2001 and 2010.

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Background: To investigate the association between proton pump inhibitor (PPI) exposure and a risk of type 2 diabetes mellitus (T2DM) among patients with upper gastrointestinal disease (UGID). Method: We conducted a case−control study from Taiwan’s National Health Insurance Research Database between 1998 and 2013. A total of 20,940 patients with T2DM and 20,940 controls were included.

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Article Synopsis
  • Autism spectrum disorder (ASD) is a significant mental health issue worldwide, with rising diagnostic rates largely influenced by improved awareness and clinical changes.
  • Data from 1990 to 2019 shows stable global prevalence rates, yet an increase in disability-adjusted life years (DALYs) in high socio-demographic index (SDI) countries, while low SDI countries show a declining incidence, stressing a need for better awareness and diagnosis.
  • The male/female ratio in ASD diagnoses has decreased, highlighting the growing recognition of ASD in females, and overall burden estimates are likely underestimated due to neglecting mortality rates in the Global Burden of Disease framework.
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