Appropriateness of Antiplatelet Therapy and Proton Pump Inhibitor Prescribing in End-Stage Kidney Disease: A Retrospective Quality Investigation Study.

Background: Patients with end-stage kidney disease (ESKD) have high rates of gastrointestinal bleeding due to several risk factors including platelet dysfunction, comorbid illness, and use of antiplatelet medications. Proton pump inhibitors (PPIs) reduce gastrointestinal bleeding and are recommended for high-risk patients such as those prescribed dual antiplatelet therapy (DAPT). Whether inappropriate duration of DAPT therapy and/or lack of appropriate PPI use contribute to the known elevated risk of gastrointestinal bleeding in hemodialysis patients is not known.

Temporal trends in disability adjusted life year and mortality for colorectal cancer attributable to a high red meat diet in China from 1990 to 2021: an analysis of the global burden of disease study 2021.

Background: High red meat consumption is a main modifiable risk factor for colorectal cancer mortality (CRC), but its attributable disease burden remains unclear in China. We aimed to analyze the temporal trends in CRC deaths and disability-adjusted life years (DALYs) attributable to high red meat consumption in China from 1990 to 2021 and to predict the disease burden in the next 15 years.

Methods: Data was obtained from the Global Burden of Disease (GBD) 2021 study.

Rational design of uniform SiO-based afterglow microparticles for photonic crystals.

Despite recent advancements in organic phosphors, the synthesis of monodisperse afterglow microparticles (MPs) suitable for creating photonic crystals remains challenging. The SiO matrix is an attractive host material for activating the long-lived emissions of doped molecules due to several factors, including its cross-linked polymer-like structure, abundance of -OH groups, robustness, and presence of numerous emitter defects. However, the Stöber method struggles to produce monodisperse molecule-doped SiO MPs due to the complexity of the system.

Double-target self-supervised clustering with multi-feature fusion for medical question texts.

Background: To make the question text represent more information and construct an end-to-end text clustering model, we propose a double-target self-supervised clustering with multi-feature fusion (MF-DSC) for texts which describe questions related to the medical field. Since medical question-and-answer data are unstructured texts and characterized by short characters and irregular language use, the features extracted by a single model cannot fully characterize the text content.

Methods: Firstly, word weights were obtained based on term frequency, and word vectors were generated according to lexical semantic information.

Dynamic Modulation of Afterglow Emission in Polymeric Phosphors via Inverse Opal Photonic Structures.

Tuning the afterglow of polymeric phosphors is critical for advancing their use in optical data storage and display technologies. Despite advancements in polymer matrix design and dopant engineering, achieving dynamic control over afterglow intensity remains a significant challenge. In this study, a novel approach is introduced for dynamically tuning the afterglow of polymeric phosphors by integrating them into an inverse opal photonic structure.

[A single-center analysis of pathogenic bacteria distribution and drug resistance in bacterial bloodstream infections among patients with hematological diseases].

To analyze the distribution and drug resistance of pathogens of bacterial bloodstream infection in patients with hematological diseases in the Department of Hematology of Tianjin Medical University General Hospital, and to provide etiological data for clinical empirical anti-infection treatment. A retrospective analysis was conducted on the general clinical information, pathogenic bacteria and drug susceptibility test results of patients with hematological diseases diagnosed with bacterial bloodstream infection by menstrual blood culture in our center from January 2016 to December 2022. Patients included 498 inpatients, with a total of 639 bacterial strains.

Hydrophobicity and Pore Structure: Unraveling the Critical Factors of Alcohol and Acid Adsorption in Zeolites.

Adsorbing and recycling alcohols and acids from industrial wastewater is of great significance in wastewater treatment; establishing the possible quantitative relationship of alcohol-acid adsorption capacity with the struct0ures of adsorbents and exploring the key factors determining their adsorption performance is very important and challenging in environment science. To solve this difficult problem, the adsorption of C1-5 alcohols, C2-4 acids, and Fischer-Tropsch synthesis (FTS) wastewater on zeolites with similar hydrophobicity and pore structures (β and MFI), similar hydrophilicity but different pore structures (Y and MOR), and similar pore structures but significant differences in hydrophobicity (MOR vs. β and MFI) was systematically investigated.

Metric geometry of spaces of persistence diagrams.

Persistence diagrams are objects that play a central role in topological data analysis. In the present article, we investigate the local and global geometric properties of spaces of persistence diagrams. In order to do this, we construct a family of functors , , that assign, to each metric pair (, ), a pointed metric space .

Sapiential battery systems: beyond traditional electrochemical energy.

As indispensable energy-storage technology in modern society, batteries play a crucial role in diverse fields of 3C products, electric vehicles, and electrochemical energy storage. However, with the growing demand for future electrochemical energy devices, lithium-ion batteries as an existing advanced battery system face a series of significant challenges, such as time-consuming manual material screening, safety concerns, performance degradation, non-access in the off-grid state, poor environmental adaptability, and pollution from waste batteries. Accordingly, incorporating the characteristics of sapiential life into batteries to construct sapiential systems is one of the most engaging tactics to tackle the above issues.

PdSe/2H-MoTe Heterojunction Self-Powered Photodetector: Broadband Photodetection and Linear/Circular Polarization Capability.

In this research, we introduce a PdSe/2H-MoTe heterojunction photodetector that exhibits both broadband self-powered photodetection and linear/circular polarization detection capabilities. It has a broad spectral response range (covering 375-2200 nm) and reaches a peak sensitivity at 532 nm, exhibiting a notable responsivity of 7.3 × 10 A/W and a substantial specific detectivity of 8.

Validation study of risk-reduction activities after personalized breast cancer education tool in the WISDOM study.

Breast cancer risk reduction strategies have been well-validated, but barriers remain for high-risk individuals to adopt them. We performed a study among participants with high risk of breast cancer to validate whether a virtual breast health decision tool impacted a participant's willingness to start risk-reducing activities, identify barriers to adopting these strategies, and understand if it affects breast cancer anxiety. The study sample was 318 participants in the personalized (investigational) arm of the Women Informed to Screen Depending on Measures of risk (WISDOM) clinical trial.

Case Report: A Chinese child with Barth syndrome caused by a novel mutation.

Barth syndrome (BTHS) is a rare X-linked recessive genetic disorder characterized by a broad spectrum of clinical features including cardiomyopathy, skeletal myopathy, neutropenia, growth delay, and 3-methylglutaconic aciduria. This disease is caused by loss-of-function mutations in the gene located on chromosome Xq28, resulting in cardiolipin deficiency. Most patients are diagnosed in childhood, and the mortality rate is highest in the early years.

Matrix-induced defects and molecular doping in the afterglow of SiO microparticles.

A deep understanding of how the host matrix influences the afterglow properties of molecule dopants is crucial for designing advanced afterglow materials. Despite its appeal, the impact of defects on the afterglow performance in molecule-doped SiO matrices has remained largely unexplored. Herein, we detail the synthesis of monodisperse SiO microparticles by hydrothermally doping molecules, such as 4-phenylpyridine, 4,4'-bipyridine, and 1,4-bis(pyrid-4-yl)benzene.

A novel GFP-based strategy to quantitate cellular spatial associations in HSV-1 viral pathogenesis.

Periodic reactivation of herpes simplex virus type 1 (HSV-1) triggers immune responses that result in corneal scarring (CS), known as herpes stromal keratitis (HSK). Despite considerable research, fully understanding HSK and eliminating it remains challenging due to a lack of comprehensive analysis of HSV-1-infected immune cells in both corneas and trigeminal ganglia (TG). We engineered a recombinant HSV-1 expressing green fluorescent protein (GFP) in the virulent McKrae virus strain that does not require corneal scarification for efficient virus replication (GFP-McKrae).

3D-printed silicate porous bioceramics promoted the polarization of M2-macrophages that enhanced the angiogenesis in bone regeneration.

The failure of bone regeneration has been considered as a serious problem that troubling patients for decades, most of which was resulted by the poor angiogenesis and chronic inflammation after surgery. Among multiple materials applied in the repair of bone defect, silicate bioceramics attracted researchers because of its excellent bioactivity. The purpose of this study was to detect the effect of specific bioactive glass ceramic (AP40, based on crystalline phases of apatite and wollastonite) on angiogenesis and the subsequent bone growth through the modulation of macrophages.

Research progress on antitumor effects of sea buckthorn, a traditional Chinese medicine homologous to food and medicine.

Sea buckthorn (), as a homologous species of medicine and food, is widely used by Mongolians and Tibetans for its anti-tumor, antioxidant and liver-protecting properties. In this review, the excellent anti-tumor effect of sea buckthorn was first found through network pharmacology, and its active components such as isorhamnetin, quercetin, gallic acid and protocatechuic acid were found to have significant anti-tumor effects. The research progress and application prospect of sea buckthorn and its active components in anti-tumor types, mechanism of action, liver protection, anti-radiation and toxicology were reviewed, providing theoretical basis for the development of sea buckthorn products in the field of anti-tumor research and clinical application.

Research on ultrasound-based radiomics: a bibliometric analysis.

Background: A large number of studies related to ultrasound-based radiomics have been published in recent years; however, a systematic bibliometric analysis of this topic has not yet been conducted. In this study, we attempted to identify the hotspots and frontiers in ultrasound-based radiomics through bibliometrics and to systematically characterize the overall framework and characteristics of studies through mapping and visualization.

Methods: A literature search was carried out in Web of Science Core Collection (WoSCC) database from January 2016 to December 2023 according to a predetermined search formula.

Association of NLRP3 and IL-4 VNTR polymorphisms and genetic susceptibility to preeclampsia: A case-control study.

Introduction: Abnormalities in the maternal immune system and insufficient gestational immune tolerance may significantly contribute to the development of preeclampsia (PE). The NLR family pyrin domain containing 3 (NLRP3) functions as a pattern recognition receptor that identifies pathogen-associated molecular patterns. Interleukin-4 (IL-4) is a potent anti-inflammatory cytokine that modulates the immune response.

[Differences and drivers of leaf stable carbon and nitrogen isotope in herbs under different vegetation types on the eastern Qinghai-Tibet Plateau].

The natural abundance of stable carbon and nitrogen isotopes (δC and δN) in leaves can provide comprehensive information on the physiological and ecological processes of plants and has been widely used in ecological research. However, recent studies on leaf δC and δN have focused mainly on woody species, few studies have been conducted on herbs in different vegetation types, and their differences and driving factors are still unclear. In this study, we focused on the herbs in subalpine coniferous forests, alpine shrublands, and alpine mea-dows on the eastern Qinghai-Tibet Plateau, and investigated the differences in leaf δC and δN of herbs and the driving factors.

Effects of disc overhang diameter on the uplift bearing capacity of new-type concrete expanded-plate pile groups.

The disc overhang diameter can significantly affect the uplift bearing capacity of new concrete expanded-plate pile groups, affecting their design and practical applications. Accordingly, this effect was investigated considering the failure laws of the soil surrounding various pile types and groups. Based on the uplift bearing capacities of single and double piles, a finite element simulation was adopted to establish models for the four-, six-, and nine-pile groups.

Oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal ERK signaling and Aβ deposition.

In clinical settings, tumor compression, trauma, surgical injury, and other types of injury can cause hypothalamic damage, resulting in various types of hypothalamic dysfunction. Impaired release of oxytocin can lead to cognitive impairment and affect prognosis and long-term quality of life after hypothalamic injury. Hypothalamic injury-induced cognitive dysfunction was detected in male animals.

Upregulated Matrisomal Proteins and Extracellular Matrix Mechanosignaling Underlie Obesity-Associated Promotion of Pancreatic Ductal Adenocarcinoma.

Diet-induced obesity (DIO) promotes pancreatic ductal adenocarcinoma (PDAC) in mice expressing KRasG12D in the pancreas (KC mice), but the precise mechanisms remain unclear. Here, we performed multiplex quantitative proteomic and phosphoproteomic analysis by liquid chromatography-tandem mass spectrometry and further bioinformatic and spatial analysis of pancreas tissues from control-fed versus DIO KC mice after 3, 6, and 9 months. Normal pancreatic parenchyma and associated proteins were steadily eliminated and the novel proteins, phosphoproteins, and signaling pathways associated with PDAC tumorigenesis increased until 6 months, when most males exhibited cancer, but females did not.

Comparison of IncK- Plasmids in Extended-Spectrum Cephalosporin-Resistant Isolated from Poultry and Humans in Denmark, Finland, and Germany.

carrying IncK- plasmids mediating resistance to extended-spectrum cephalosporins (ESC) has been frequently described in food-producing animals and in humans. This study aimed to characterize IncK--positive ESC-resistant isolates from poultry production systems in Denmark, Finland, and Germany, as well as from Danish human blood infections, and further compare their plasmids. Whole-genome sequencing (Illumina) of all isolates ( = 46) confirmed the presence of the gene.

The immunologic abnormalities in patients with paroxysmal nocturnal hemoglobinuria are associated with disease progression.

Objectives: To suggest the presence of a hyperimmune state in patients, and indicate that immune system attack on glycosylphosphatidylinositol (+) (GPI) cells while escaping GPI cell immunity.

Methods: We retrospective the immune cell subtypes in peripheral blood from 25 patients visiting Tianjin Medical University General Hospital, Tianjin, China, with classical paroxysmal nocturnal hemoglobinuria (PNH) and 50 healthy controls.

Results: The total CD3 and CD3CD8 cell levels were higher in patients with PNH.