Publications by authors named "Chayenne H A M Veerman"
Article Synopsis
- The study aimed to evaluate the effects of continuing long-acting somatostatin analogues (LA-SSAs) during peptide receptor radionuclide therapy (PRRT) on the uptake of a specific radioactive compound used in treatment.
- Patients were divided into three groups based on whether they had stopped LA-SSAs more than 6 weeks prior to PRRT or continued with either octreotide or lanreotide less than 6 weeks prior.
- The results showed that while the uptake of the compound was significantly reduced in healthy liver and spleen tissues in patients using LA-SSAs, it did not affect the uptake in tumor lesions, indicating that LA-SSAs do not interfere with the effectiveness of PRRT
Background: Receptor saturation during peptide receptor radionuclide therapy (PRRT) could result in altered [Lu]Lu-HA-DOTATATE uptake in tumors and organs. Therefore, receptor expression status and effects of different (unlabeled) administered peptide amounts during PRRT need to be evaluated. The aim of this study was to assess potential receptor saturation during PRRT by comparing organ and tumor uptake after administration of [Lu]Lu-HA-DOTATATE with low, standard and high administered peptide amounts in patients with advanced metastatic neuroendocrine tumors (NETs).
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