Publications by authors named "Chayapat Malee"
Background: Plasmodium vivax is the dominant Plasmodium spp. causing malaria throughout tropical and sub-tropical countries. Humoral immunity is induced during P.
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- P. vivax malaria significantly impacts health and development in tropical regions, prompting interest in pre-erythrocytic vaccines that could help control or eliminate the disease.
- Researchers evaluated immune responses to five recombinant PE antigens in individuals from low transmission areas in Thailand, finding that certain antibodies surged during infections but declined over time, with some persistence noted.
- The study provided insights into the durability and types of antibody responses, particularly noting that high levels of IgG1 and IgG3 subclasses remained detectable for at least a year post-infection, informing future vaccine development efforts.
Article Synopsis
- Plasmodium vivax Duffy Binding Protein region II (PvDBPII) is a promising target for a malaria vaccine because antibodies against it may prevent the parasite from invading red blood cells.
- Researchers conducted three studies on individuals who recovered from P. vivax infection to analyze the T cell immune responses specifically targeting PvDBPII, finding six key T cell epitopes that produced strong responses.
- The analysis revealed that certain amino acid changes in these epitopes affected T cell memory responses, and while antibodies against PvDBPII were common during acute infection, they decreased over time, indicating a potential pathway for developing a more effective malaria vaccine.