Publications by authors named "Chayanan Tangsombun"
Article Synopsis
- A new low-molecular-weight gelator (LMWG) made from a modified amino acid and an aldehyde can incorporate different active pharmaceutical ingredients (APIs) in distinct ways.
- Basic APIs like propranolol and atropine can mix with the gelator before it forms a gel, while acidic APIs like naproxen and rosuvastatin disrupt its bonding and must be incorporated afterward.
- Atropine showed effective release properties and holds promise for use in treating conditions like myopia, indicating the potential for further research and development using these supramolecular gels.
We report the use of acid-diffusion to assemble core-shell supramolecular gel beads with different low-molecular-weight gelators (LMWGs) in the core and shell. These gel beads grow a shell of dibenzylidenesorbitol-based DBS-COOH onto a core comprising DBS-CONHNH and agarose that has been loaded with acetic acid. Diffusion of the acid from the core triggers shell assembly.
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