Cross-sectional evaluation of a large-scale antimicrobial stewardship trial in Australian companion animal practices.

Background: Antimicrobial stewardship programmes (ASPs) are critically important for improving the appropriate use of antimicrobial agents in veterinary practice.

Methods: One of three ASPs was implemented in 135 Australian general veterinary practices in 2018-2020. The ASP interventions and the perceived impact they had on antimicrobial prescribing were assessed by the veterinarians working in these veterinary practices.

Antimicrobial stewardship in companion animal practice: an implementation trial in 135 general practice veterinary clinics.

Background: Antimicrobial stewardship programmes (ASPs) have been widely implemented in medical practice to improve antimicrobial prescribing and reduce selection for multidrug-resistant pathogens.

Objectives: To implement different antimicrobial stewardship intervention packages in 135 veterinary practices and assess their impact on antimicrobial prescribing.

Methods: In October 2018, general veterinary clinics were assigned to one of three levels of ASP, education only (CON), intermediate (AMS1) or intensive (AMS2).

Platinum Complexes with Chelating Acyclic Aminocarbene Ligands Work as Catalysts for Hydrosilylation of Alkynes.

This work describes the preparation of a series of platinum-aminocarbene complexes [PtCl{C(N=C (CRRRRCON ))=N(H)R}(CNR)] (-, 65-75% isolated yield) via the reaction of -[PtCl(CNR)] (R = Cy , -Bu , Xyl , 2-Cl-6-MeCH ) with 3-iminoisoindolin-1-ones HN=C (CRRRRCON H) (R-R = H ; R = Me, R, R, R = H ; R, R = Cl, R, R = H ). New complexes - were characterized by elemental analyses (C, H, N), ESI-MS, Fourier transform infrared spectroscopy (FT-IR), one-dimensional (H, C{H}), and two-dimensional (H,H correlation spectroscopy (COSY), H,C heteronuclear multiple quantum correlation (HMQC)/H,C heteronuclear single quantum coherence (HSQC), H,C heteronuclear multiple bond correlation (HMBC)) NMR spectroscopy, and authenticity of known species - was confirmed by FT-IR and H and C{H} NMR. Complexes - were assessed as catalysts for hydrosilylation of terminal alkynes with hydrosilanes to give vinyl silanes, and complex [PtCl{C(N=C (CH(5-Me)CON ))=N(H)(2-Cl-6-MeCH)}{CN(2-Cl-6-MeCH)}] () showed the highest catalytic activity.

Metal Azolate/Carboxylate Frameworks as Catalysts in Oxidative and C-C Coupling Reactions.

The five metal azolate/carboxylate (MAC) compounds [Cd(dmpzc)(DMF)(H2O)] (Cd-dmpzc), [Pd(H2dmpzc)2Cl2] (Pd-dmpzc), [Cu(Hdmpzc)2] (Cu-dmpzc), [Zn4O(dmpzc)3]·Solv (Zn-dmpzc·S), and [Co4O(dmpzc)3]·Solv (Co-dmpzc·S) were isolated by coupling 3,5-dimethyl-1H-pyrazol-4-carboxylic acid (H2dmpzc) to cadmium(II), palladium(II), copper(II), zinc(II), and cobalt(II) salts. While Cd-dmpzc and Pd-dmpzc had never been prepared in the past, for Cu-dmpzc, Zn-dmpzc·S, and Co-dmpzc·S we optimized alternative synthetic paths that, in the case of the copper(II) and cobalt(II) derivatives, are faster and grant higher yields than the previously reported ones. The crystal structure details were determined ab initio (Cd-dmpzc and Pd-dmpzc) or refined (Cu-dmpzc, Zn-dmpzc·S, and Co-dmpzc·S) by means of powder X-ray diffraction (PXRD).