Navigating the unseen: An aneurysm striking neurosurgeon.

The irony of life is that in the complex world of neurosurgery, where the skilled mind of the neurosurgeon navigates the delicate terrain of cerebral aneurysm, the same mind can be affected by the very thing it treats. Sometimes the healer becomes the one in need of healing. This predicament highlights the reality of existence that vulnerability transcends professional boundaries, and any individual can become a target.

Enhancing Trauma Care in Tertiary Hospitals: Addressing Gaps and Pathways to Improvement.

Trauma is a major cause of morbidity and mortality globally, with road traffic accidents projected to be the leading cause of death by 2030. In developing countries like Pakistan, trauma patients face significant challenges in receiving timely and effective care. This study aimed to evaluate trauma centers in tertiary care hospitals in the twin cities of Pakistan to highlight gaps and pitfalls in trauma patient management.

Ethical Concerns of AI in Neurosurgery: A Systematic Review.

Background: The relentless integration of Artificial Intelligence (AI) into neurosurgery necessitates a meticulous exploration of the associated ethical concerns. This systematic review focuses on synthesizing empirical studies, reviews, and opinion pieces from the past decade, offering a nuanced understanding of the evolving intersection between AI and neurosurgical ethics.

Materials And Methods: Following PRISMA guidelines, a systematic review was conducted to identify studies addressing AI in neurosurgery, emphasizing ethical dimensions.

Choosing the Path: Insights Into Zambian Medical Students' Specialty Selections.

Background: The specialization of medical students is essential for enhancing healthcare quality, and meeting the diverse needs of patients, with medical training programs significantly influencing their career trajectories and expertise development. This study aimed to investigate the future specialty preferences of medical students from various medical schools in Zambia.

Materials And Methods: The study included participants from seven medical schools who had completed at least their first clinical clerkship.

Cryptic presentation: primary amoebic meningoencephalitis mimicking a high-grade malignancy resulting in surgical fatality within 48 hours. Illustrative case.

Background: A 71-year-old male presented with weakness of the right upper limb and headache for the past 3 months. Brain magnetic resonance imaging (MRI) with contrast showed a left frontal space-occupying lesion, suggestive of a high-grade malignancy. Awake craniotomy with complete excision of the lesion was performed under immunofluorescence guidance.

Microvascular decompression: a contemporary update.

Background: Microvascular decompression (MVD) is the gold-standard surgical treatment for cranial nerve compression disorders, including trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia (GPN). This review synthesizes historical milestones, recent advances, and evolving techniques in MVD, with a primary focus on these conditions.

Methods: A comprehensive literature review was conducted using databases such as PubMed, SpringerLink, Google Scholar, BioMed Central, Scopus, and ScienceDirect.

Intracranial ependymoma: A retrospective analysis of clinical features, treatment modalities, and long-term outcome.

Objective: Ependymomas, rare neuroglial tumors originating from ependymal cells, can occur in the CNS and typically affect the brain's ventricles or spinal cord. Prognosis is influenced by tumor grade, location, resection extent, and preoperative Karnofsky Performance Status Scale (KPSS) scores. This study evaluates clinical features, treatment outcomes, and factors affecting prognosis in patients with intracranial ependymomas.

Efficacy and safety of Cerebrospinal drains in preventing and managing spinal cord ischemia and Injury: a comprehensive systematic review and meta-analysis.

Spinal cord ischemia and injury pose significant challenges in spinal surgery and traumatic events. Cerebrospinal drains are considered a potential intervention to mitigate these risks, although their efficacy and safety are uncertain. We conducted a comprehensive systematic review and meta-analysis to evaluate the efficacy and safety of cerebrospinal drains in preventing and managing spinal cord ischemia and injury.

Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta-Analysis.

Background: Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off-label for chemotherapy-induced pain. We conducted this systematic review and meta-analysis aiming to test the current evidence regarding effectiveness and safety of duloxetine for postspine surgeries pain.

Methods: We searched the Cochrane Central Register of Controlled Trials, PubMed, Scopus and Web of science databases for relevant articles up to March 2024.

Intraoperative variations in intra-axial brain tumor size after craniotomy: a prospective study with histopathological and tumor tissue composition correlation, introducing concepts of tumor expansion and tumor surfacing.

Intraoperative assessment of tumor margins can be challenging; as neoplastic cells may extend beyond the margins seen on preoperative imaging. Real-time intraoperative ultrasonography (IOUS) has emerged as a valuable tool for delineating tumor boundaries during surgery. However, concerns remain regarding its ability to accurately distinguish between tumor margins, peritumoral edema, and normal brain tissue.

Adherence in Evidence-Based Neurotrauma Guidelines: A Worldwide Survey.

Background: Traumatic brain injury management guidelines vary across regions and there is limited research on real-world adherence to these guidelines. We conducted a global survey to assess the adherence of neurosurgeons to traumatic brain injury guidelines and evidence-based medicine (EBM).

Methods: A 24-item survey was created using Google Forms, covering demographic information, neurotrauma training, basic knowledge of EBM, and surgical and in-hospital management.

Chronic traumatic encephalopathy in athletes, players, boxers and military: systematic review.

The objective of the study was to demonstrate whether athletes, players, boxers and military personnel can really be victims of Chronic traumatic encephalopathy (CTE), and to elucidate this pathology. In 53 articles, 14 were selected for qualitative synthesis in the results table that addresses CTE in football, soccer and rugby players, boxers and the military. Neuropathologically, CTE shows cerebral atrophy, a pelvic septum cavity with fenestrations, dense diffuse immunoreactive inclusions and a TDP-43 proteinopathy.

Biomarkers for autism spectrum disorder: a short review.

Background: Autism spectrum disorder (ASD) is characterized by social disabilities and stereotyped behaviors. There is a relevant social impact on autistic people's lives and, therefore, biomarkers have become relevant for understanding neurobiological mechanisms.

Objective: This study aims to review current knowledge about the role of biomarkers and their main scientific evidence in autism.

Intracranial aneurysm coexisting with pituitary adenoma: a systematic review.

Introduction: The simultaneous occurrence of intracranial aneurysms (IA) and primary brain tumors (BT) is frequently reported, with an estimated incidence of 0.5-7.4%.

A "Mismatched" connection: a rare case of indirect or dural carotid-cavernous fistula: a case based review.

Introduction And Importance: A carotid-cavernous sinus fistula is an abnormal connection between the internal or external carotid artery and the venous system of the cavernous sinus. It represents a rare entity, and it is often misdiagnosed due to its overlapping symptoms with other conditions such as cavernous sinus thrombosis or orbital inflammation. Cerebral angiography continues to be the gold standard for diagnosis and surgical planning in patients with CCF, and the endovascular trans-venous approach still represents the primary line of treatment.

Dandy-Walker syndrome: a bibliometric analysis of the most 100 cited articles.

Introduction: Dandy-Walker syndrome (DWS), a complex neurodevelopmental disorder, has intrigued clinicians and researchers since its description by physicians Walter Dandy and Arthur Walker. Despite its recognition for nearly a century, understanding its etiology, pathogenesis, and clinical manifestations remains elusive. This bibliometric analysis aims to elucidate influential academic works on DWS.

Two-stage surgical approach for type III odontoid fracture with C1-C2 fracture dislocation: a case report and management overview.

Introduction And Importance: Odontoid fractures of the second cervical vertebra (C2) are categorized into three types, with type III extending into the body of the axis. These fractures, often resulting from high-energy trauma, can cause significant instability and neurological issues. This case report discusses a 43-year-old male with a type III odontoid fracture and C1-C2 fracture dislocation, demonstrating the effectiveness of traditional neurosurgical techniques in managing such complex injuries.

A systematic review of radiological prediction of ki 67 proliferation index of meningioma.

Objective: Radiological prediction of Ki-67 plays a crucial role in determining the clinical outcomes of meningioma patients. The aim of this review is to comprehensively review the literature to synthesize evidence on how accurate radiological prediction of the Ki-67 proliferation index is to determine the Ki-67 index's association with clinical outcomes of meningioma.

Materials And Methods: A narrative synthesis systematic review followed PRISMA guidelines.