Publications by authors named "Chaudry N Majeed"
Article Synopsis
- Small interfering RNAs (siRNAs) are tiny RNA pieces that can make messenger RNA (mRNA) disappear, which helps control how much protein is made in our bodies.
- Givosiran is a special siRNA that helps treat a rare liver disease called acute hepatic porphyrias by targeting a specific part of the liver that creates toxic substances.
- The text talks about how givosiran works, its successful test results, and its importance for treating this disease and potentially helping with other medical problems in the future.
Given the ongoing strain that the obesity epidemic has placed on public health outcomes, new and effective approaches to weight control are needed. One approach to improving weight and metabolic outcomes is intermittent fasting, which consists of multiple different timing schedules for temporary food avoidance, including alternate-day fasting, other similar full-day fasting patterns, and time-restricted feeding (where the day's food is consumed over a 6-h period, allowing for 18 h of fasting). These feeding schedules have favorable metabolic effects by intermittently inducing the metabolism of fatty acids to ketones.
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- A meta-analysis was conducted to compare the minimalist and standard approaches to transcatheter aortic valve replacement (TAVR) using studies up to September 2020.
- The analysis included 9 studies with 2,880 patients and found that the minimalist approach showed reduced risks for complications such as acute kidney injury, major bleeding, and major vascular issues.
- Although there were no significant differences in mortality or readmission rates, the minimalist approach resulted in shorter hospital stays, less procedural time, and lower contrast volume used.
Article Synopsis
- Cirrhotic coagulopathy involves both procoagulant and anticoagulant deficiencies, complicating bleeding risks in patients with liver cirrhosis.
- The study analyzed 29 research articles involving 13,276 cirrhotic patients to examine the link between international normalized ratio (INR) and periprocedural bleeding risks.
- Findings revealed no significant correlation between pre-procedural INR levels and bleeding events, suggesting INR is not a reliable predictor, and highlighting the need for future research to improve patient care and minimize unnecessary blood transfusions.
Objective: The association of bilirubin with cardiovascular disease (CVD) is controversial. We sought to explore the association of total bilirubin (TB) levels with QT interval in a multiracial cohort.
Methods: A total of 6,627 participants (59.
Article Synopsis
- * The analysis involved 1,416 comatose cardiac arrest patients, revealing that 44% had pre-existing HF, and those treated with hypothermia had a higher mortality rate of 75.4% compared to 53.2% for those who did not receive it.
- * The results indicated that hypothermia significantly increased mortality risk for HF patients (HR 1.69) but not for non-HF patients, especially among those with shockable cardiac rhythms.
Although the link between marital status and mortality is well established, the pathophysiological basis is unclear. An investigation of the association of marital status with prolonged QT interval may highlight the underlying mechanism for poor outcomes associated with being unmarried. This analysis included 6,562 participants (mean age 58.
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