Hydroclimatic extremes threaten groundwater quality and stability.

Heavy precipitation, drought, and other hydroclimatic extremes occur more frequently than in the past climate reference period (1961-1990). Given their strong effect on groundwater recharge dynamics, these phenomena increase the vulnerability of groundwater quantity and quality. Over the course of the past decade, we have documented changes in the composition of dissolved organic matter in groundwater.

Corrigendum: Interplay of various evolutionary modes in genome diversification and adaptive evolution of the family .

[This corrects the article DOI: 10.3389/fmicb.2021.

Old but not ancient: Rock-leached organic carbon drives groundwater microbiomes.

More than 90% of earth's microbial biomass resides in the continental subsurface, where sedimentary rocks provide the largest source of organic carbon (C). While many studies indicate microbial utilization of fossil C sources, the extent to which rock-organic C is driving microbial activities in aquifers remains largely unknown. Here we incubated oxic and anoxic groundwater with crushed carbonate rocks from the host aquifer and an outcrop rock of the unsaturated zone characterized by higher organic C content, and compared the natural abundance of radiocarbon (C) of available C pools and microbial biomarkers.

Jute-Copper Nanocomposite Embedded PSf Membrane for Sustainable and Efficient Heavy Metal Removal from Water Sources.

Numerous corporations have overlooked environmental regulations concerning wastewater treatment, leading to a worldwide issue regarding hazardous pollutant discharge, particularly dyes and heavy metal ions, into river sources. Various industries, with water, energy, and biological sectors, actively employ membranes. Membranes capable of showing flux, metal and dye sorption, and catalysis have been developed and are extensively used by functionalizing the pores of ultrafiltration, microfiltration, and nanofiltration membranes with responsive properties.

HF-free low-temperature synthesis of MXene for electrochemical hydrogen production.

MXenes [two-dimensional (2D) transition-metal carbides, nitrides and carbonitrides] are gaining significant interest as alternative electrocatalysts for the hydrogen evolution reaction due to their excellent properties such as high electrical conductivity, large surface area and chemical stability. MXenes are traditionally synthesized using hydrofluoric acid (HF), which raises safety and environmental concerns due to its highly corrosive and toxic nature. HF introduces fluoride functional groups on the surface of MXenes, and these have been reported to have a detrimental effect on electrocatalysis.

Anatomic Interpretability in Neuroimage Deep Learning: Saliency Approaches for Typical Aging and Traumatic Brain Injury.

The black box nature of deep neural networks (DNNs) makes researchers and clinicians hesitant to rely on their findings. Saliency maps can enhance DNN explainability by suggesting the anatomic localization of relevant brain features. This study compares seven popular attribution-based saliency approaches to assign neuroanatomic interpretability to DNNs that estimate biological brain age (BA) from magnetic resonance imaging (MRI).

Anatomic Interpretability in Neuroimage Deep Learning: Saliency Approaches for Typical Aging and Traumatic Brain Injury.

The black box nature of deep neural networks (DNNs) makes researchers and clinicians hesitant to rely on their findings. Saliency maps can enhance DNN explainability by suggesting the anatomic localization of relevant brain features. This study compares seven popular attribution-based saliency approaches to assign neuroanatomic interpretability to DNNs that estimate biological brain age (BA) from magnetic resonance imaging (MRI).

Surface modification of a biomass-derived self-supported carbon nano network as an emerging platform for advanced field emitter devices and supercapacitor applications.

Herein, a self-supported carbon network is designed through the sole pyrolysis of Carica papaya seeds (biomass) without any activation agent, demonstrating their field emission and supercapacitor applications. The pyrolysis of seeds in an argon atmosphere leads to the formation of interconnected, rod-like structures. Furthermore, the hydrofluoric acid treatment not only removed impurities, but also resulted in the formation of CaF nanocrystals with the addition of F-doping.

Neuroanatomical and clinical factors predicting future cognitive impairment.

Identifying cognitively normal (CN) older adults who will convert to cognitive impairment (CI) due to Alzheimer's disease is crucial for early intervention. Clinical and neuroimaging measures were acquired from 301 CN adults who converted to CI within 15 years of baseline, and 294 who did not. Regional volumes and brain age measures were extracted from T-weighted magnetic resonance images.

Anomalous Flexor Carpi Radialis Tendons Giving Rise to a Novel Surgical Technique in the Treatment of Thumb Carpometacarpal Joint Arthritis: A Case Report.

Introduction: Incidental discovery of anomalous muscles and anatomical variants within the forearm and wrist through surgical exposure and advanced imaging techniques is relatively common.

Case Report: The patient presented with pain and swelling in her hand that was refractory to rest and anti-inflammatory medications. Here, we describe the intraoperative discovery of an anatomical variant of the flexor carpi radialis (FCR), as well as an anomalous flexor carpi radialis brevis (FCRB) in a 58-year-old patient being treated for thumb carpometacarpal joint (CMCJ) arthritis.

Genome streamlining in Parcubacteria transitioning from soil to groundwater.

Background: To better understand the influence of habitat on the genetic content of bacteria, with a focus on members of Candidate Phyla Radiation (CPR) bacteria, we studied the effects of transitioning from soil via seepage waters to groundwater on genomic composition of ultra-small Parcubacteria, the dominating CPR class in seepage waters, using genome resolved metagenomics.

Results: Bacterial metagenome-assembled genomes (MAGs), (318 total, 32 of Parcubacteria) were generated from seepage waters and compared directly to groundwater counterparts. The estimated average genome sizes of members of major phyla Proteobacteria, Bacteroidota and Cand.

Piperacillin-Tazobactam-Induced Urticaria and Angioedema: A Case Report With Literature Review.

Drug-induced urticaria and angioedema cases are typically reversible upon discontinuation and can be triggered by antibiotics, angiotensin-converting enzyme inhibitors, or nonsteroidal anti-inflammatory drugs. Piperacillin-tazobactam, a common broad-spectrum antimicrobial, has been linked to severe adverse reactions, such as thrombocytopenia, hemolytic anemia, and Steven Johnson syndrome in some cases. A 35-year-old male presented to the emergency department with fever, cough, and acute breathlessness, complicating his ongoing treatment for pulmonary tuberculosis with bedaquiline and delamanid.

Control-Etched TiCT MXene Nanosheets for a Low-Voltage-Operating Flexible Memristor for Efficient Neuromorphic Computation.

Hardware neural networks with mechanical flexibility are promising next-generation computing systems for smart wearable electronics. Overcoming the challenge of developing a fully synaptic plastic network, we demonstrate a low-operating-voltage PET/ITO/p-MXene/Ag flexible memristor device by controlling the etching of aluminum metal ions in TiCT MXene. The presence of a small fraction of Al ions in partially etched MXene (p-TiCT) significantly suppresses the operating voltage to 1 V compared to 7 V from fully Al etched MXene (f-TiCT)-based devices.

Identification and Connectomic Profiling of Concussion Using Bayesian Machine Learning.

Accurate early diagnosis of concussion is useful to prevent sequelae and improve neurocognitive outcomes. Early after head impact, concussion diagnosis may be doubtful in persons whose neurological, neuroradiological, and/or neurocognitive examinations are equivocal. Such individuals can benefit from novel accurate assessments that complement clinical diagnostics.

G4-Ligand-Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures.

G-quadruplex (G4) DNA structures are prevalent secondary DNA structures implicated in fundamental cellular functions, such as replication and transcription. Furthermore, G4 structures are directly correlated to human diseases such as cancer and have been highlighted as promising therapeutic targets for their ability to regulate disease-causing genes, e.g.

Prediction of cognitive outcome after mild traumatic brain injury from acute measures of communication within brain networks.

A considerable but ill-defined proportion of patients with mild traumatic brain injury (mTBI) experience persistent cognitive sequelae; the ability to identify such individuals early can help their neurorehabilitation. Here we tested the hypothesis that acute measures of efficient communication within brain networks are associated with patients' risk for unfavorable cognitive outcome six months after mTBI. Diffusion and T-weighted magnetic resonance imaging, alongside cognitive measures, were obtained to map connectomes both one week and six months post injury in 113 adult patients with mTBI (71 males).

Effectiveness of topical gabapentin in the treatment of vulvodynia: a narrative synthesis.

Vulvodynia is a leading cause of dyspareunia in premenopausal women, causing considerable morbidity and sexual dysfunction. A multimodal approach is used to treat vulvodynia. Alongside psychosocial interventions and physiotherapy, pharmacological treatment such as oral gabapentin are used in the treatment of vulvodynia.

Differential contribution of nitrifying prokaryotes to groundwater nitrification.

The ecophysiology of complete ammonia-oxidizing bacteria (CMX) of the genus Nitrospira and their widespread occurrence in groundwater suggests that CMX bacteria have a competitive advantage over ammonia-oxidizing bacteria (AOB) and archaea (AOA) in these environments. However, the specific contribution of their activity to nitrification processes has remained unclear. We aimed to disentangle the contribution of CMX, AOA and AOB to nitrification and to identify the environmental drivers of their niche differentiation at different levels of ammonium and oxygen in oligotrophic carbonate rock aquifers.

ACL Reconstruction in a Poliotic Limb with Peroneus Longus Graft.

Introduction: Prevalence of polio was very high in India before its eradication, with a number of people living with its residual effects. Anterior cruciate ligament (ACL) injury is the most common knee injury. To the best of our knowledge, this is the first report in literature presenting ACL injury in a poliotic limb and its management.

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells.

Mitochondrial DNA (mtDNA) replication stalling is considered an initial step in the formation of mtDNA deletions that associate with genetic inherited disorders and aging. However, the molecular details of how stalled replication forks lead to mtDNA deletions accumulation are still unclear. Mitochondrial DNA deletion breakpoints preferentially occur at sequence motifs predicted to form G-quadruplexes (G4s), four-stranded nucleic acid structures that can fold in guanine-rich regions.

Trimetallic Oxide Foam as an Efficient Catalyst for Fixation of CO into Oxazolidinone: An Experimental and Theoretical Approach.

The excess anthropogenic CO depletion via the catalytic approach to produce valuable chemicals is an industrially challenging, demanding, and encouraging strategy for CO fixation. Herein, we demonstrate a selective one-pot strategy for CO fixation into "oxazolidinone" by employing stable porous trimetallic oxide foam (PTOF) as a new catalyst. The PTOF catalyst was synthesized by a solution combustion method using transition metals Cu, Co, and Ni and systematically characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), field emission scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HR-TEM), N sorption, temperature-programmed desorption (TPD), and X-ray photoelectron spectroscopy (XPS) analysis.

covery and vival of patients with moderate to severe acute spiratory distress syndrome (ARDS) due to OVID-19: a multicenter, single-arm, Phase IV itolizumab rial: .

Background: Itolizumab, an anti-CD6 monoclonal antibody, down-regulates COVID-19-mediated inflammation and the acute effects of cytokine release syndrome. This study aimed to evaluate the safety and efficacy of itolizumab in hospitalized COVID-19 patients with PaO/FiO ratio (PFR) ≤200 requiring oxygen therapy.

Research Design And Methods: This multicenter, single-arm, Phase 4 study enrolled 300 hospitalized adults with SARS-CoV-2 infection, PFR ≤200, oxygen saturation ≤94%, and ≥1 elevated inflammatory markers from 17 COVID-19 specific tertiary Indian hospitals.