Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones.

This study presents the reactions of adrenocorticosteroids (cortisol and aldosterone) and sex steroids [testosterone, androstenedione, and dehydroepiandrosterone and its sulfate (DHAS)] 1) to a dexamethasone (Dex) treatment, which is expected to lower steroid levels via the ACTH blockade, and 2) to an exercise bout at maximal O(2) consumption, which is expected to increase steroid production via ACTH stimulation. Consistent with the decrease in ACTH, all steroids except testosterone reacted negatively to Dex, independently of the dose (0.5 and 1.

Dexamethasone in resting and exercising men. I. Effects on bioenergetics, minerals, and related hormones.

A placebo and a low and a high dose of dexamethasone (Dex) were administered for 4.5 days, at 3-wk intervals, to 24 healthy men, following a double-blind, random-order, crossover procedure. After the last dose the subjects performed a maximal cycling exercise, during which respiratory exchanges, electrocardiogram, and blood pressures were monitored.

[Psychometric evaluation of depression in the elderly subject: which instruments? What are the future perspectives?].

Depression in the elderly is frequent but often unknown (in 30 to 50% of the cases) because of difficulties in detecting or diagnosing it. This is due to the clinical features and prognosis of depression in this kind of population but also to the non-existence of specific diagnostic tests. Most of the authors consider that the most useful diagnostic tests are screening assessments.

A method for determining the maximal steady state of blood lactate concentration from two levels of submaximal exercise.

The aim of this study was to estimate the characteristic exercise intensity (WCL) which produces the maximal steady state of blood lactate concentration (MLSS) from submaximal intensities of 20 min carried out on the same day and separated by 40 min. Ten fit male adults [maximal oxygen uptake (VO2max) 62 (SD 7) ml.min-1.

Angiotensin-converting enzyme inhibition does not suppress plasma angiotensin II increase during exercise in humans.

Physical effort stimulates the reninangiotensin system (RAS). We studied the effect of an angiotensin-converting enzyme inhibitor (ACE inhibitor) in a double-blind placebo-controlled study, on eight volunteers undergoing physical stress on an ergometric bicycle. The effects of captopril (C) (50 mg, three times daily for 3 days) on arterial pressure (AP), O2 consumption (VO2), variations in auricular natriuretic factor (ANF), renin, angiotensin II (AII) plasma levels, as well as glomerular filtration rate (GFR) and microalbuminuria (MA) were evaluated.

[Blood lactate in the steeplechase horse: triangular and rectangular series of steps during short duration races].

Five steeplechase race horses were observed during incremental and constant-load exercises with the aim of separating effects of work rate and time on blood lactate. Each independent exercise (an incremental and three constant load tests) was a sequence of three two-minute runs, separated by two one-minute rest intervals for jugular blood sampling. The following observations were made: 1.

[The value of respiratory function tests in the surveillance of asthmatic children].

The purpose of pulmonary function testing in children with asthma is to search for obstructive airway disease. We examined the charts of 169 asthmatic children during intervals between acute exacerbations. The severity of asthma was determined according to VIALATTE classification, with the Tiffeneau ration FEV1/VC (1) and the MMFR/VC ratio serving as obstructive indices.

[Stability and variation of the maximal ventilation and maximal expiratory volume ratios].

The level of stability of the ratio (alpha coefficient) of maximal ventilation (MBC) over maximal expiratory volume per second (FEV1) was continued statistically for its practical value in estimating the respiratory functional incapacity. Three observations were made: --the mean value of the alpha coefficient=MBC/FEV1 is independent of the sex, age, size or weight in the normal subject; alpha was slightly higher than that found from theoretical values of MBC (CECA) and FEV1 (BALDWIN and COURNAND); --the alpha coefficient varied with the vital capacity (VC) and with FEV1; --there was a particularly simple relation between alpha and VC: alpha decreased from 38 to 30 when VC increased from 1 to 6 litres.