Publications by authors named "Charulata Bawankule"

Article Synopsis
  • * A case of a 54-year-old man with type 2 diabetes showed worsening pain in his calf, where tests confirmed muscle injury and inflammation as the cause of his symptoms.
  • * Treatment included hemodialysis, medications for pain and blood sugar control, and lifestyle changes, highlighting the need for early diagnosis and management of DMI to prevent complications.
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  • Carpenter syndrome is a rare autosomal recessive disorder caused by RAB23 mutations, marked by features like craniofacial anomalies, heart disease, brachydactyly, and obesity.
  • With an incidence of about one in a million births, diagnosing this syndrome can be difficult due to its variety of symptoms.
  • This case report connects Carpenter syndrome to chronic kidney disease (CKD), highlighting the need for more research on the genetic links and clinical management of these conditions.
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  • - The case report highlights a 48-year-old woman with chronic kidney disease who developed pure red cell aplasia (PRCA) due to anti-erythropoietin (EPO) antibodies after receiving EPO injections for anemia.
  • - Following a severe drop in her hemoglobin levels, she was treated with desidustat, a new oral medication that improved her hemoglobin significantly while being less likely to induce an immune response.
  • - This case emphasizes the importance of quick diagnosis and the potential of desidustat as a safer alternative for treating anemia in patients, showcasing advancements in treatment within the context of the first reported case in India.
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  • Erythrocytosis, a rare side effect of SGLT2 inhibitors like dapagliflozin, is often overlooked in diabetic patients with chronic kidney disease (CKD), despite its documented occurrence.
  • The report highlights two cases where erythrocytosis developed quickly in CKD patients on dapagliflozin, suggesting a need for increased vigilance from healthcare providers.
  • Effective management involves regular hemoglobin monitoring and prompt discontinuation of the medication to prevent complications, advocating for routine blood evaluations in CKD patients undergoing SGLT2i treatment.
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Bortezomib is a frequently administered immunosuppressive agent in kidney transplantation. A 30-year-old male kidney transplant recipient developed an atypical reaction on the left hand in terms of spider-like extensions, indicating erythematous inflammation along the superficial veins after bortezomib intravenous administration. The inflammation spontaneously resolved after three weeks with a bortezomib dose reduction.

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  • Maintenance hemodialysis (MHD) patients are at higher risk for severe COVID-19, and this study evaluated the antibody response to the COVISHIELD vaccine after two doses.
  • Among 50 MHD patients, 96% showed seropositivity, with those having a prior COVID-19 infection exhibiting significantly higher antibody levels.
  • The COVISHIELD vaccine proved to be effective and safe, with mild adverse events reported in one-third of patients but no serious complications.
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Autoimmune diseases may act as a trigger for atypical hemolytic uremic syndrome (aHUS). Triggers for aHUS may include autoimmune diseases, infections, metabolic conditions, pregnancy, and transplants. aHUS-mediated injury to various organs, especially kidneys, can be life-threatening.

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  • Kidney transplants are a key treatment for end-stage renal disease, but conditions like atypical hemolytic uremic syndrome (aHUS) can complicate outcomes and increase rejection risks.
  • This case study discusses a young adult with aHUS who successfully received an ABO-incompatible kidney transplant, thanks to a method of desensitization that lowered the risk of rejection.
  • The patient was given triple immunosuppressive therapy, and after four months, follow-up tests showed no signs of rejection or recurrence of aHUS, proving that ABO-incompatible transplants can be done safely in such patients.
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  • * A study analyzed 47 patients with aHUS, finding that 5 underwent kidney transplants, with most diagnosed before the procedure; only one had a recurrence post-transplant.
  • * Pre-transplant treatments like plasma exchange and rituximab showed promise in minimizing disease severity and promoting good kidney function after transplant, with no reported recurrences during follow-up.
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Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disorder triggered by various stressors. Most of the time, stressors may not be identified in patients with aHUS. The disease may remain quiescent without manifestation throughout life.

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  • Tacrolimus is a crucial medication for kidney transplant patients, with its metabolism influenced by genetic variations in the CYP3A5 gene.
  • A study analyzed 25 kidney transplant patients based on their CYP3A5 genetic polymorphism status, classifying them into three groups: non-expressers, intermediate expressers, and expressers.
  • The findings revealed that non-expressers required higher tacrolimus doses, experienced more complications like urinary tract infections and diabetes, and highlighted the importance of genetic testing for tailored medication plans.
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Unlabelled: The incidence of kidney disease patterns diagnosed by kidney biopsy depends on age, gender, race, socioeconomic, nutritional, and environmental factors. The present study was performed at a tertiary care teaching hospital in central India to show the current frequency of different types of kidney diseases through histopathological findings.

Materials And Methods: We carried out a retrospective analysis of kidney biopsies done in our institute between January 2016 and June 2021, and clinical and histopathological correlation was done from the available medical records.

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The pattern of glomerular disease differs in incidence among the different geographical areas because of ethnicity, genetic variability, environmental factors, and socioeconomic conditions. The prevalence of pattern glomerular diseases varies from different parts of the world and from within the same country, the current study was performed to show the frequency of occurrence of primary and secondary glomerular disease (SGD) observed in a tertiary care hospital catering to patients from central India. In a retrospective study, we analyzed the clinical and pathological data of 176 kidney biopsies that were performed from 2016 to 2019 at the Department of Nephrology Super Speciality Hospital in Nagpur.

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Kimura's disease (KD) usually presents with a subcutaneous swelling and associated lymphadenopathy in the periauricular area. KD has a tendency to involve the kidneys. Proteinuria is reported in 12%-16% of cases, and around 60%-70% of them develop nephrotic range proteinuria.

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In the absence of a national registry, the exact incidence and burden of chronic kidney disease in children in India is not known. The most common diagnosis for which children are likely to see a pediatric nephrologist is nephrotic syndrome constituting almost 40% of cases. Considering all the renal manifestations in the pediatric age group, we designed simply survey to find out the awareness among school going children about the kidney's function and dysfunction in our Indian scenario.

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Guillain-Barré syndrome (GBS) has been associated with both infective and noninfective etiologies. It is usually preceded by acute gastrointestinal or respiratory infections. We report an unusual case of GBS in a hepatitis C virus-positive hemodialysis (HD)-dependent patient who was being treated with sofosbuvir and daclatasvir along with antitubercular drugs for pulmonary tuberculosis.

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Primary hyperparathyroidism (PHPT) usually presents with hypercalcemia related symptoms and signs. Kidneys play an important role in calcium homeostasis. PHPT has been reported to be associated with hyperchloremia, defective urinary acidification, and renal tubular acidosis (RTA).

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We report a case of systemic lupus erythematosus (SLE) who presented with rapidly progressive renal failure (RPRF) with positive antinuclear antibody (ANA) and anti-double-stranded DNA (dsDNA) antibody and active urinary sediment in the form of microscopic hematuria and proteinuria. Provisional clinical diagnosis of lupus nephritis was made. Renal biopsy showed pauci-immune crescentic glomerulonephritis, the diagnosis of which was supported by positive serum anti-MPO antibody.

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Echinococcosis is a parasitic infection caused by the larval stage of a cestode and is endemic in sheep farming regions of developing countries. It manifests as hydatid cyst and most commonly is found in liver followed by lungs. Renal hydatid cyst is rare and amounts for 2% of all cases.

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