[Cryptococcosis. A study of 9 strains of Cryptococcus neoformans isolated from immunodeficient patients].

Five strains of Cryptococcus neoformans isolated from the cerebro-spinal fluid and 4 from the blood of AIDS patients, were studied. Although morphologically identical, they differed in the auxanographic pattern. All strains were pathogenic for mice by intracerebral route.

Ketoconazole resistance in Torulopsis glabrata.

The majority of clinical isolates of T. glabrata has been shown highly sensitive to ketoconazole, when tested with an agar dilution method, and resistant, when using a broth dilution method. The fact was accounted for the high degree of mutation associated with the haploid state present in this species.

The oxidase test in yeasts of medical importance.

The results of an oxidase test were positive with species of Cryptococcus and eight species of Candida, but negative with Candida krusei and species of Saccharomyces and Torulopsis, grown on Columbia Agar base and similar media, including Brain Heart Infusion Agar and Mueller Hinton Agar. When grown on Sabouraud Dextrose Agar, all the yeast genera and species were oxidase negative. The test is useful in delineating the genus Candida from Saccharomyces and Torulopsis.