A comprehensive review of in planta stable transformation strategies.

Plant transformation remains a major bottleneck to the improvement of plant science, both on fundamental and practical levels. The recalcitrant nature of most commercial and minor crops to genetic transformation slows scientific progress for a large range of crops that are essential for food security on a global scale. Over the years, novel stable transformation strategies loosely grouped under the term "in planta" have been proposed and validated in a large number of model (e.

Safety and feasibility of intravenous sotalol loading for the prevention of ventricular arrhythmias.

Background: The use of intravenous (IV) sotalol loading following recent U.S. Food and Drug Administration (FDA) approval of a 1-day loading protocol has reduced the obligatory 3-day hospital stay for sotalol initiation when given orally.

Body Composition and Maximal Strength of Powerlifters: A Descriptive Quantitative and Longitudinal Study.

The purpose of this study was to present the relationships between maximal strength and body composition and to conduct yearly follow-ups presenting the chronic effects of maximal strength training on body composition. Thirty-four (age = 28.8 ± 8.

Cost-Effectiveness of Icosapent Ethyl (IPE) for the Reduction of the Risk of Ischemic Cardiovascular Events in Canada.

Background: Despite the use of statins, many patients with cardiovascular disease (CVD) have persistent residual risk. In a large Phase III trial (REDUCE-IT), icosapent ethyl (IPE) was shown to reduce the first occurrence of the primary composite endpoint of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or hospitalization for unstable angina.

Methods: We conducted a cost-utility analysis comparing IPE to placebo in statin-treated patients with elevated triglycerides, from a publicly funded, Canadian healthcare payer perspective, using a time-dependent Markov transition model over a 20-year time horizon.

Comparative transcriptome analysis reveals the biocontrol mechanism of Bacillus velezensis E68 against Fusarium graminearum DAOMC 180378, the causal agent of Fusarium head blight.

Fusarium graminearum is the causal agent of Fusarium Head Blight, a serious disease affecting grain crops worldwide. Biological control involves the use of microorganisms to combat plant pathogens such as F. graminearum.

Implementation of an intravenous sotalol initiation protocol: Implications for feasibility, safety, and length of stay.

Introduction: Oral sotalol initiation requires a multiple-day, inpatient admission to monitor for QT prolongation during loading. A 1-day intravenous (IV) sotalol loading protocol was approved by the United States Food and Drug Administration in March 2020, but limited data on clinical use and administration currently exists. This study describes implementation of an IV sotalol protocol within an integrated health system, provides initial efficacy and safety outcomes, and examines length of stay (LOS) compared with oral sotalol initiation.

Interpol Review Paper of Marks and Impression Evidence 2019-2022.

This section contains an overview of publications relevant to advances in scientific methods and general discussions concerning shoe and toolmark examiners, which were published between January 2019 and May of 2022 and is the sequel to the review for the 19th Interpol International Forensic Science Managers Symposium in 2019 by Martin Baiker-Sorensen. A literature search was conducted covering relevant articles published in the main forensic journals.

Bacillus velezensis strain B26 modulates the inflorescence and root architecture of Brachypodium distachyon via hormone homeostasis.

Plant growth-promoting rhizobacteria (PGPR) influence plant health. However, the genotypic variations in host organisms affect their response to PGPR. To understand the genotypic effect, we screened four diverse B.

MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with Acute Respiratory Distress Syndrome Outcome.

Acute respiratory distress syndrome (ARDS) remains a significant problem in need of new pharmaceutical approaches to improve its resolution. Studies comparing gene expression signatures in rodents and humans with lung injury reveal conserved pathways, including MAPK (mitogen-activated protein kinase)/ERK (extracellular signal-related protein kinase) activation. In preclinical acute lung injury (ALI) models, inhibition of MAP2K1 (MAPK kinase 1)/MAP2K2 (MAPK kinase 2) improves measures of ALI.

Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation.

MEK1 and MEK2, the only known activators of ERK, are attractive therapeutic candidates for both cancer and autoimmune diseases. However, how MEK signaling finely regulates immune cell activation is only partially understood. To address this question, we specifically delete Mek1 in hematopoietic cells in the Mek2 null background.

Genotyping by sequencing suggests overwintering of Peronospora destructor in southwestern Québec, Canada.

Several Peronospora species are carried by wind over short and long distances, from warmer climates where they survive on living plants to cooler climates. In eastern Canada, this annual flow of sporangia was thought to be the main source of Peronospora destructor responsible for onion downy mildew. However, the results of a recent study showed that the increasing frequency of onion downy mildew epidemics in eastern Canada is associated with warmer autumns, milder winters, and previous year disease severity, suggesting overwintering of the inoculum in an area where the pathogen is not known to be endogenous.

Notification of STI test results by text messaging: Why do patients refuse? Cross-sectional study in a Parisian sexual health centre.

Text messaging has been used to notify patients of results after sexually transmitted infection (STI) testing. This study aimed to characterise the population who refused notification of results by short message services (SMS) and to explore their reasons for refusing. From January to August 2018, 1180 patients coming for STI testing in a Parisian sexual health centre were offered SMS notification of their results, completed a self-administered questionnaire and were included in the study.

Ectopic cilia in 112 dogs: A multicenter retrospective study.

Objective: The aim of this retrospective study was to review the clinical data and outcomes of patients that suffered ectopic cilium (EC).

Animals Studied: One hundred and twelve dogs from multiple private practices in France, with a clinical diagnosis of EC were included in the study.

Results: The mean age of affected dogs was 2.

N-methyl-d-aspartate (NMDA) receptor genetics: The power of paralog homology and protein dynamics in defining dominant genetic variants.

Predicting genotype-to-phenotype correlations from genomic variants has been challenging, particularly for genes that have a complex balance of dominant and recessive inheritance for phenotypes. Variants in NMDA receptor components GRIN1, GRIN2A, and GRIN2B cause a myriad of dominant disease phenotypes, with the most common being epilepsy and autism spectrum disorder. Starting from the analysis of a variant of uncertain significance (VUS, GRIN2A G760S), we realized the need for tools to map dominant variants for the components of the NMDA receptor.

Ice Hockey Goaltender Physiology Profile and Physical Testing: A Systematic Review and Meta-Analysis.

This review aims to 1) be the first systematic review and meta-analysis of the literature examining the physiology and assessment of goaltenders, and 2) present a physiological profile of ice-hockey goaltenders. It will 1) highlight physiological differences between goaltenders and players at other positions, 2) determine strengths and weaknesses of ice hockey goaltenders, and 3) offer possible guidelines for strength and conditioning coaches. Six electronic databases were systematically searched in October 2019 using the PRISMA model.

and Functional Redundancy in Erythropoiesis.

Several studies have established the crucial role of the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase pathway in hematopoietic cell proliferation and differentiation. MEK1 and MEK2 phosphorylate and activate ERK1 and ERK2. However, whether MEK1 and MEK2 differentially regulate these processes is unknown.

Shrinkage Mitigation of an Ultra-High Performance Concrete Submitted to Various Mixing and Curing Conditions.

Ultra-High Performance Concretes (UHPC) are cement-based materials with a very low water-to-binder ratio that present a very-high compressive strength, high tensile strength and ductility as well as excellent durability, making them very interesting for various civil engineering applications. However, one drawback of UHPC is their pretty high autogenous shrinkage stemming from their very low water-to-binder ratio. There are several options to reduce UHPC shrinkage, such as the use of fibers (steel fibers, polypropylene fibers, wollastonite microfibers), shrinkage-reducing admixtures (SRA), expansive admixtures (EA), saturated lightweight aggregates (SLWA) and superabsorbent polymers (SAP).

Unclear outcomes of heart rate variability following a concussion: a systematic review.

Purpose: : To systematically regroup articles that were published since the latest systematic search, but with specific inclusion criteria to help comparison that will offer a focused presentation of methods and results. This will offer a full overview of HRV's behavior at rest and during exercise in adults post-concussion.

Methods: : The systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) method.

mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.

mTOR, the sensor of nutrients and growth factors, has important roles in tissue homeostasis and tumorigenesis. However, how mTOR controls gastric epithelial cell turnover and gastric cancer development, a leading malignancy, remains poorly understood. Here, we provide genetic evidence that mTOR activation promotes proliferation and inhibits differentiation of Lgr5 gastric epithelial progenitors (GEPs) in gastric homeostasis and tumorigenesis.