Publications by authors named "Charmaine M Huckabee"
Article Synopsis
- A clinical trial tested the effectiveness and safety of omalizumab, an anti-IgE antibody, for treating multiple food allergies in individuals aged 1 to 55, primarily focusing on its ability to allow safe consumption of peanuts and other allergic foods.
- Out of 462 people screened, 177 children and adolescents completed the study, with 67% of those on omalizumab successfully consuming 600 mg of peanut protein without severe reactions, compared to only 7% of the placebo group.
- The results showed similar success rates for other allergenic foods (cashew, milk, and egg), with overall safety profiles being comparable, though more injection-site reactions were reported in those receiving omalizumab.
Background: The multicenter, cluster-randomized Strategies to Reduce Transmission of Antimicrobial Resistant Bacteria in Intensive Care Units (STAR*ICU) trial was performed in 18 U.S. adult intensive care units (ICUs).
View Article and Find Full Text PDFBackground: Intensive care units (ICUs) are high-risk settings for the transmission of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE).
Methods: In a cluster-randomized trial, we evaluated the effect of surveillance for MRSA and VRE colonization and of the expanded use of barrier precautions (intervention) as compared with existing practice (control) on the incidence of MRSA or VRE colonization or infection in adult ICUs. Surveillance cultures were obtained from patients in all participating ICUs; the results were reported only to ICUs assigned to the intervention.
We analyzed surveillance cultures for vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) collected during a multicenter trial to determine if three negative cultures collected at weekly intervals would predict clearance of VRE or MRSA from colonized patients. Seventy-two percent of VRE-colonized patients and 94% of MRSA-colonized patients were culture negative after three consecutive negative cultures.
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