Fixel-based and tensor-derived white matter abnormalities in relation to memory impairment and neurocognitive disorders.

Aging-related neurocognitive disorders, including Alzheimer's disease (AD) and mild cognitive impairment (MCI), have been characterised by altered brain white matter (WM), relying widely on diffusion tensor imaging (DTI). DTI's limited accuracy in assessing crossing fibres prompted novel methods that distinguish fibres crossing through same voxel-spaces, such as fixel-based analysis (FBA), highlighting subtle macrostructural and microstructural alterations in AD and MCI. We examined the FBA and DTI's specificity in determining WM features relevant to memory in the neurocognitive aging spectrum.

Examining cognition and brain networks using magnetoencephalography in paediatric autoimmune encephalitis and acute disseminated encephalomyelitis: a preliminary study.

Paediatric autoimmune encephalitis, including acute disseminated encephalomyelitis, are inflammatory brain diseases presenting with cognitive deficits, psychiatric symptoms, seizures, MRI and EEG abnormalities. Despite improvements in disease recognition and early immunotherapy, long-term outcomes in paediatric autoimmune encephalitis remain poor. Our aim was to understand functional connectivity changes that could be associated with negative developmental outcomes across different types of paediatric autoimmune encephalitis using magnetoencephalography.

The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging.

Alterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas.