Scientific discovery, peak experiences and the Col-oh-nell Flastratus! phenomenon.

Once I had a bizarre dream in which I was vouchsafed a secret which would ensure my wealth and success. It was the title for a comic novel; one supposedly so funny that it would guarantee classic status for any book: Oh Colonel Flastratus! The distinctive feature about my dream was its quality of profound significance, which felt akin to the Eureka moment of a scientific discovery. This led me to question whether the 'peak experience' (PE) of scientific discovery might be as delusional as my dream.

Psychological neoteny and higher education: associations with delayed parenthood.

In a recent Medical Hypotheses editorial, I suggested the name psychological neoteny (PN) to refer to the widely-observed phenomenon that adults in modernizing liberal democracies increasingly retain many of the attitudes and behaviors traditionally associated with youth. I further suggested that PN is a useful trait for both individuals and the culture in modernizing societies; because people need to be somewhat child-like in their psychology order to keep learning, developing and adapting to the rapid and accelerating pace of change. Thirdly, I put forward the hypothesis that the major cause of PN in modernizing societies is the prolonged duration of formal education.

Measuring revolutionary biomedical science 1992-2006 using Nobel prizes, Lasker (clinical medicine) awards and Gairdner awards (NLG metric).

The Nobel prize for medicine or physiology, the Lasker award for clinical medicine, and the Gairdner international award are given to individuals for their role in developing theories, technologies and discoveries which have changed the direction of biomedical science. These distinctions have been used to develop an NLG metric to measure research performance and trends in 'revolutionary' biomedical science with the aim of identifying the premier revolutionary science research institutions and nations from 1992-2006. I have previously argued that the number of Nobel laureates in the biomedical field should be expanded to about nine per year and the NLG metric attempts to predict the possible results of such an expansion.

Which are the best nations and institutions for revolutionary science 1987-2006? Analysis using a combined metric of Nobel prizes, Fields medals, Lasker awards and Turing awards (NFLT metric).

I have previously suggested that Nobel prizes can be used as a scientometric measurement of 'revolutionary science'; and that for this purpose it would be better if more Nobel prizes were awarded, especially in three new subjects of mathematics, medicine and computing science which have become major sciences over recent decades. In the following analysis of the last 20 years from 1987 to 2006, I use three prestigious prizes in mathematics (Fields medal), medicine (Lasker award for Clinical Medical Research) and computing science (A.M.

Scientometric identification of elite 'revolutionary science' research institutions by analysis of trends in Nobel prizes 1947-2006.

Most research is 'normal science' using Thomas Kuhn's term: checking, trial-and-error improvement and incremental extrapolation of already existing paradigms. By contrast, 'revolutionary science' changes the fundamental structures of science by making new theories, discoveries or technologies. Science Nobel prizes (in Physics, Chemistry, Physiology/Medicine and Economics) have the potential to be used as a new metric for measuring revolutionary science.

Alienation, recovered animism and altered states of consciousness.

Alienation is the feeling that life is 'meaningless', that we do not belong in the world. But alienation is not an inevitable part of the human condition: some people do feel at one with the world as a consequence of the animistic way of thinking which is shared by children and hunter-gatherers. Animism considers all significant entities to have 'minds', to be 'alive', to be sentient agents.

Why there should be more science Nobel prizes and laureates - And why proportionate credit should be awarded to institutions.

The four science Nobel prizes (physics, chemistry, medicine/physiology and economics) have performed extremely well as a method of recognizing the highest level of achievement. The prizes exist primarily to honour individuals but also have a very important function in science generally. In particular, the institutions and nations which have educated, nurtured or supported many Nobel laureates can be identified as elite in world science.

From Nutty Professor to Buddy Love--Personality types in modern science.

People often suggest that scientists should have a specific personality type, usually conscientious and self-critical. But this is a mistake. Science as a social system needs to be conscientious and self-critical, but scientists as people do not necessarily have to conform to that stereotype.

Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection.

Staphylococcus aureus is a major cause of surgical wound infections. The development of mechanisms of antimicrobial resistance by this and other bacterial pathogens has prompted the search for new approaches to treat infectious diseases. Hyaluronic acid binding peptides have been shown to modulate cellular trafficking during host responses and were assessed for their ability to treat and possibly prevent experimental surgical wound infections caused by S.

Mega-prizes in medicine: big cash awards may stimulate useful and rapid therapeutic innovation.

Following Horrobin's suggestion of 1986, I argue that offering very large prizes (tens of millions of US dollars, or more) for solving specific therapeutic problems, would be an excellent strategy for promoting the rapid development of effective new treatments. The two mainstream ways of paying for medical research are funding the process with grants or funding the outcome via patent protection. When grants are used to fund the process of research the result tends to be 'pure' science, guided by intrinsic scientific objectives.

Persistence of immunity in commercial egg-laying hens following vaccination with a killed H6N2 avian influenza vaccine.

The California poultry industry experienced an outbreak of H6N2 avian influenza beginning in February 2000. The initial infections were detected in three commercial egg-laying flocks and a single noncommercial backyard flock but later spread to new premises. The vaccination of pullet flocks with a commercially prepared, killed autogenous vaccine prior to their placements on farms with infected or previously infected flocks was used as a part of the eradication programs for some multiage, commercial egg production farms.

Lectures are such an effective teaching method because they exploit evolved human psychology to improve learning.

Lectures are probably the best teaching method for many students in many circumstances; especially for communicating conceptual knowledge, and where there is a significant knowledge gap between lecturer and audience. However, the lack of a convincing rationale has been a factor in under-estimating the importance of lectures, and there are many who advocate their replacement with written communications or electronic media. I suggest that lectures are so effective because they exploit the spontaneous human aptitude for learning from spoken (rather than written) information.

The rise of the boy-genius: psychological neoteny, science and modern life.

The mid-20th century saw the rise of the boy-genius, probably because a personality type characterized by prolonged youthfulness is advantageous both in science and modern life generally. This is the evolution of 'psychological neoteny', in which ever-more people retain for ever-longer the characteristic behaviours and attitudes of earlier developmental stages. Whereas traditional societies are characterized by initiation ceremonies marking the advent of adulthood, these have now dwindled and disappeared.

The busy shall inherit the earth: the evolution from 'hard work' to 'busyness' in modern science and society.

Although 'hard work' and 'busyness' are somewhat similar terms, there seem to be significant differences in the way that they are used. While hard work has always been a feature of complex societies, modern society can be seen as evolving toward being dominated by jobs characterized by busyness. Busyness refers to multi-tasking - having many sequential jobs to perform and switching frequently between them on an externally-imposed schedule.

Why are doctors still prescribing neuroleptics?

There are two main pharmacological methods of suppressing undesired behaviour: sedation or neuroleptics. Traditionally, the invention of neuroleptics has been hailed as one of the major clinical breakthroughs of the twentieth century, since they calmed agitation without (necessarily) causing sedation. The specifically neuroleptic form of behavioural control is achieved by making patients psychologically Parkinsonian, which entails emotional blunting and consequent demotivation.

Despite their inevitable conflicts--science, religion and New Age spirituality are essentially compatible and complementary activities.

Until recently it seemed that the continued expansion of scientific ways of thinking was destined to render religion extinct and spirituality unfeasible. But the example of the United States disproves this, since America is the most successful scientific nation of this era, church-going remains strong and New Age spiritualities are thriving. Therefore, despite the obvious conflicts; science, religion and spirituality are essentially compatible.

Why medical research needs a new specialty of 'pure medical science'.

Sciences tend to go through boom and bust phases. Following decades of rapid expansion, medical science is now due for a collapse in overall funding. Furthermore, there has been a decline in the rate of therapeutic innovation, with fewer significant breakthroughs and little progress in several major areas of medicine such as oncology, psychiatry and autoimmune disorders.

The paradox of the modern mass media: probably the major source of social cohesion in liberal democracies, even though its content is often socially divisive.

The modern mass media (MM) is often regarded a mixture between a trivial waste of time and resources, and a dangerously subversive system tending to promote social division and community breakdown. But these negative evaluations are difficult to square with the fact that those countries with the largest mass media include the most modernized and powerful nations. It seems more plausible that the MM is serving some useful - perhaps vital - function.

Scientific life should be measured in seven year units.

Traditional wisdom and empirical observation unite in recommending a 7 year unit for measuring human life - including individual and institutional science. But, because of astronomy and the decimal system, things tend to be measured either in years, five years or in decades. A year is too short while a decade is too long to measure the trends and transitions of individual or institutional life.

Science school and culture school: improving the efficiency of high school science teaching in a system of mass science education.

Educational expansion in western countries has been achieved mainly by adding years to full-time education; however, this process has probably reduced efficiency. Sooner or later, efficiency must improve, with a greater educational attainment per year. Future societies will probably wish more people to study science throughout high school (aged c.

Globalization in science education: an inevitable and beneficial trend.

Globalization is one aspect of the larger phenomenon of modernization, which describes societies characterized by progressive growth in the complexity of communications. Despite its inevitable problems, globalization is a generally desirable phenomenon, since it enables increased efficiency, effectiveness and capability of societies and thereby, potentially benefits most people most of the time. Scientific research was one of the first global communication systems, especially at its most advanced levels.

Medicine and the space odyssey.

Up to the mid-1960s, science and technology (including medicine) were generally regarded as exciting, beautiful and spiritually enthralling; and the space odyssey seemed a symbol of the optimistic future of humankind. The early seventies saw a growing disillusionment with space travel as part of a mood of cultural pessimism and anti-modernization - and this combined with a resurgence of therapeutic nihilism in medicine. But recent discussions of renewed space exploration and a Mars mission may be evidence of a changing zeitgeist, with Western culture moving towards a bolder and more optimistic attitude.

Science as a general education: Conceptual science should constitute the compulsory core of multi-disciplinary undergraduate degrees.

It is plausible to assume that in the future science will form the compulsory core element both of school curricula and multi-disciplinary undergraduate degrees. But for this to happen entails a shift in the emphasis and methods of science teaching, away from the traditional concern with educating specialists and professionals. Traditional science teaching was essentially vocational, designed to provide precise and comprehensive scientific knowledge for practical application.