Publications by authors named "Charlotte-Aimee Young"
Association of Retinal Nerve Fiber Layer Thinning With Elevated High Density Lipoprotein Cholesterol in UK Biobank.
Invest Ophthalmol Vis Sci
September 2024
Article Synopsis
- - The study aimed to explore the relationship between retinal nerve fiber layer (RNFL) thickness and high-density lipoprotein cholesterol (HDL-C) levels in a healthy population of 31,738 UK Biobank participants, using advanced imaging techniques.
- - Results showed that high HDL-C levels were linked to thinner RNFL thickness in both men and women, while moderate HDL-C levels were positively associated with thicker RNFL in women, indicating a complex relationship between cholesterol and eye health.
- - The findings suggest that elevated HDL-C could be a potential risk factor for neurodegenerative diseases, highlighting its importance for preventive healthcare strategies.
Article Synopsis
- The study aimed to assess the prevalence and severity of depressive and anxiety symptoms among caregivers of children with congenital ectopia lentis (CEL), identifying potential risk factors.
- Over half of the caregivers reported some level of depressive or anxiety symptoms, with a notable percentage experiencing moderate to severe cases, especially those caring for children with systemic abnormalities.
- The findings highlight the strong correlation between depressive and anxiety symptoms, emphasizing the need for screening and psychological support for caregivers of children with CEL.
Aims: This study aims to investigate the associations between commonly used systemic medications and diabetic retinopathy (DR).
Methods: Individuals with linked primary care prescription data from the UK Biobank were included. Cases were defined as individuals with a Hospital Episode Statistics-coded or primary care recorded diagnosis of DR or self-reported DR.
Purpose: To derive an effective nomogram for predicting Marfan syndrome (MFS) in children with congenital ectopia lentis (CEL) using regularly collected data.
Methods: Diagnostic standards (Ghent nosology) and genetic test were applied in all patients with CEL to determine the presence or absence of MFS. Three potential MFS predictors were tested and chosen to build a prediction model using logistic regression.
Background: Congenital ectopia lentis (CEL) is a hereditary eye disease which severely impacts preschool children's visual function and development. This study aimed to evaluate the longitudinal changes in spherical equivalent (SE) refractive error in preschool children with CEL.
Methods: A retrospective cohort study was conducted at Zhongshan Ophthalmic Center, Guangzhou, China.
Objectives: This study aims to evaluate the effect of congenital ectopia lentis (CEL) on functional vision and eye-related quality of life (ER-QOL) in children and their families using the Paediatric Eye Questionnaire (PedEyeQ).
Design: A questionnaire survey administered via in-person interviews of patients with CEL and their parents.
Participants: 51 children with CEL and 53 visually normal controls accompanied by 1 parent completed the survey questionnaires for the study from March 2022 to September 2022.
Purpose: To systematically review the literature and quantitatively synthesize the currently available evidence to compare the accuracy of different intraocular lens calculation formulas in eyes with long axial length (AL).
Design: Network meta-analysis.
Methods: PubMed, Embase, Web of Science, and the Cochrane Library were systematically searched for studies published between January 2000 and June 2022.
Weill-Marchesani syndrome (WMS) manifests as ectopia lentis (EL), microspherophakia and short stature, which is caused by ADAMTS10, LTBP2, or ADAMTS17 gene defects. This study aims to investigate the characteristics and genotype-phenotype correlations of WMS with ADAMTS17 mutations. WMS patients with ADAMTS17 variants were identified by whole-exome sequencing from 185 patients with EL.
View Article and Find Full Text PDFIntroduction: Congenital ectopia lentis (CEL) is a rare ocular disease characterised by the dislocation or displacement of the lens. Patients with mild lens dislocations can be treated with conservative methods (eg, corrective eyeglasses or contact lenses). In contrast, patients with severe CEL usually require surgical management.
View Article and Find Full Text PDFArticle Synopsis
- - The study estimated the disease burden of cataract by analyzing its prevalence and disability-adjusted life years (DALYs) using data from the Global Burden of Disease study 2019, focusing on trends from 1990 to 2019.
- - It found that global rates of visual impairment and DALYs due to cataract have significantly increased, with prevalence rising by 58.45% and DALYs by 32.18% over the observed period.
- - Key factors contributing to the higher disease burden were identified, including increased prevalence of refractive errors, fewer physicians per population, and lower human development index (HDI), indicating a need for improved surgical efforts in low-socioeconomic areas.
Purpose: To introduce a method of predicting effective lens position (ELP) among congenital ectopia lentis (CEL) patients undergoing transscleral fixation of intraocular lens (IOL), and evaluate its effect on improving refractive outcome by utilizing the Sanders-Retzlaff-Kraff / theoretical (SRK/T) formula.
Design: Retrospective cross-sectional study.
Methods: A training set (93 eyes) and validation set (25 eyes) was included.
Purpose: To provide evidence for future strategies in preventing glaucomatous blindness by investigating the disease burden in terms of age, year, and gender from 1990 to 2019 in China.
Methods: The prevalence and disability-adjusted life years (DALYs) of blindness and vision loss due to glaucoma in China were extracted from the Global Burden of Disease (GBD) 2019 study. Age-standardized data is presented in comparison to China's neighboring countries.
Article Synopsis
- - The study examines the rising trends in drug use disorders (DUDs) over 30 years, highlighting a global increase in disability-adjusted life-years (DALYs) by about 2.6% annually from 1990 to 2019, with opioid disorders being the most significant contributor among five categories of DUDs.
- - Researchers utilized data from the Global Burden of Disease Study 2019 and performed regression analyses to explore correlations between DUDs and socio-economic factors, finding that a higher inequality-adjusted human development index is a significant risk factor.
- - The findings indicate that while overall burdens from DUDs have grown, age-standardized rates have remained stable, suggesting a need for targeted public health policies
Purpose: To investigate the longitudinal changes and associated factors of axial length (AL) in congenital ectopia lentis (CEL) patients.
Methods: In this retrospective study, medical records of CEL patients were reviewed from January 2014 to December 2019 at the Zhongshan Ophthalmic (ZOC) in China. Patients were divided into the surgery group and the nonsurgery group.
Purpose: To compare the accuracy of intraocular lens (IOL) power calculation formulas in eyes with congenital ectopia lentis (CEL) that underwent scleral-fixated IOL implantation.
Setting: Zhongshan Ophthalmic Center, Guangzhou, China.
Design: Retrospective consecutive case-series study.
Purpose: The purpose of this study was to assess whether migraine might be associated with the increased risk of dry eye disease and to determine the strength of the association between migraine and dry eye disease.
Methods: We searched EMBASE, PubMed, Web of Science databases and China National Knowledge Infrastructure, WanFang, and VIP databases for studies that investigated the association between dry eye and migraine from inception to September 8, 2020. Relevant data were extracted by 2 investigators independently.
Purpose: To investigate the burden of near vision loss (NVL) in China by year, age and gender from 1990 to 2019.
Methods: We used estimates from the Global Burden of Disease (GBD) 2019 study to report the prevalence and disability-adjusted life-years (DALYs) due to NVL in China. Estimates of crude counts and age-standardised rates per 100 000 population are accompanied by 95% uncertainty intervals (UIs).
Purpose: To evaluate the epidemiological trends and associated risk factors of disease burden due to trachoma.
Methods: Data for the country-specific disability-adjusted life year (DALY) number, rate and age-standardised rate of trachoma together with related data of other common eye diseases were acquired from the Global Burden of Disease Study 2019 database. The Socio-Demographic Index (SDI), Human Development Index (HDI), inequality-adjusted HDI and other related indices were obtained from published data or publicly available databases.
Purpose: The purpose of this study was to investigate the characteristics of corneal higher-order aberrations (HOAs) in patients with congenital ectopia lentis (CEL).
Methods: Clinical characteristics and HOAs of 60 patients with CEL and 75 healthy controls at Zhongshan Ophthalmic Center in China were retrospectively analyzed. The Q value and the corneal HOAs in the CEL group and the controls were measured by using Pentacam and compared value between the CEL and control groups.
Purpose: To investigate the association of all reported common polymorphisms in anti-vascular endothelial growth factor (VEGF) therapy response and to identify potential clinically useful biomarkers for anti-VEGF therapy response in patients with age-related macular degeneration (AMD).
Methods: We searched the Embase, PubMed, Web of Science databases in English and the China National Knowledge Infrastructure, WanFang and VIP databases in Chinese for pharmacogenetics studies on anti-VEGF therapy response in AMD. Odds ratios with 95% confidence intervals were calculated using the random effects model.
Background: To investigate the prevalence and time trends of refractive error (RE) among Chinese children under 18 years old.
Methods: PubMed, Embase, Web of Science were searched for articles that estimated prevalence of RE in Chinese children. Data of identified eligible studies was extracted by two investigators independently.
Although it is widely known that hypertension is an important cause of chronic kidney disease (CKD), little detailed quantitative research exists on the burden of CKD due to hypertension. The objective of the study is to estimate the global disease burden of CKD due to hypertension and to evaluate the association between the socioeconomic factors and country-level disease burden of CKD due to hypertension. We extracted the disability-adjusted life-year (DALY) numbers, rates, and age-standardized rates of CKD due to hypertension from the Global Burden of Disease Study 2019 database to investigate the time trends of the burden of CKD due to hypertension from 1990 to 2019.
View Article and Find Full Text PDFBackground: To evaluate the prevalence of visual impairment (VI) among elderly Chinese population.
Methods: All population-based studies on VI prevalence among elderly Chinese populations were searched and only studies with clear definitions of diagnosis were selected. Meta-analysis methods were used to estimate the pooled prevalence and its 95% confidence interval (95%CI) of moderate and severe visual impairment (MSVI) and blindness both by presenting visual acuity (PVA) and best corrected visual acuity (BCVA).
Background: There is no consensus on which intraocular lens (IOL) power calculation formula provides the best refractive prediction in patients with inadequate capsular support whose anterior ocular anatomic structure differs from that of normal subjects. Therefore, the purpose of this study was to analyze the accuracy and performance of IOL calculation formulas (SRK/T, Holladay 1, Hoffer Q, Haigis, and Barrett Universal II) in predicting postoperative refractive prediction error (PE) for this subgroup of patients.
Methods: A total of 110 eyes from 110 patients with insufficient capsular support who underwent scleral fixation of an IOL at the Zhongshan Ophthalmic Center from July 1, 2016 to November 30, 2019 were enrolled in this retrospective study.