Lt: A Resource to Future-Proof the Laboratory in Uncertain Times.

The COVID-19 pandemic abruptly challenged educators to transition previously in-person courses to an online environment. This has been especially difficult for laboratory courses where students must experience the process of science to develop lab skills and scientific competencies. Due to the uncertainty caused by the pandemic, it is essential that instructional resources are flexible and robust for use in various potential learning environments.

Predictors and rates of PTSD, depression and anxiety in UK frontline health and social care workers during COVID-19.

: Studies have shown that working in frontline healthcare roles during epidemics and pandemics was associated with PTSD, depression, anxiety, and other mental health disorders. : The objectives of this study were to identify demographic, work-related and other predictors for clinically significant PTSD, depression, and anxiety during the COVID-19 pandemic in UK frontline health and social care workers (HSCWs), and to compare rates of distress across different groups of HCSWs working in different roles and settings. : A convenience sample () of frontline UK HCSWs completed an online survey during the first wave of the pandemic (27 May - 23 July 2020).

Emotion recognition and mind wandering in adults with attention deficit hyperactivity disorder or autism spectrum disorder.

Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in adults are often undiagnosed and overlap in psychopathology. Here we investigated the transdiagnostic traits of emotion recognition and mind wandering in a sample of 103 adults (43 with ADHD and 14 with ASD). The ability to correctly identify a facial expression of anger, fear, disgust or surprise was no different between the adults with ADHD or ASD and neurotypical (NT) adults.

Increased nuclear permeability is a driver for age-related motoneuron loss.

Sarcopenia is the loss of skeletal muscle mass with age, the precise cause of which remains unclear. Several studies have shown that sarcopenia is at least partly driven by denervation which, in turn, is related to loss of motor nerve cells. Recent data suggests degradation of the nucleocytoplasmic barrier and nuclear envelope transport process are contributors to nerve loss in a number of neurodegenerative diseases.

Exercise attenuates age-associated changes in motoneuron number, nucleocytoplasmic transport proteins and neuromuscular health.

Life expectancy continues to extend, although frailty caused by loss of skeletal muscle mass continues unimpeded. Muscle atrophy caused by withdrawal of motor nerves is a feature of old age, as it is in amyotrophic lateral sclerosis (ALS) in which skeletal muscle denervation results from motoneuron death. In ALS, direct links have been established between motoneuron death and altered nucleocytoplasmic transport, so we ask whether similar defects accompany motoneuron death in normal ageing.