Multiple Sclerosis Disease Activity and Disability Following Discontinuation of Natalizumab for Pregnancy.

Importance: The magnitude of risk of pregnancy-related multiple sclerosis relapses, particularly severe relapses, following natalizumab cessation is unclear, as is whether this risk is reduced by pregnancy or other modifiable factors.

Objective: To determine the association of early natalizumab withdrawal before or during pregnancy with risk of severe relapses and relapse-related disability.

Design, Setting, And Participants: This prospective cohort study used data from the German Multiple Sclerosis and Pregnancy Registry, which enrolled participants between November 2006 and February 2018.

Mechanical thrombectomy in a young stroke patient with Duchenne muscular dystrophy.

Background: Duchenne muscular dystrophy (DMD) is an X-linked recessive skeletal muscle myopathy which is caused by mutations in the dystrophin gene. Lack of dystrophin also results to cardiomyopathy, which raises significantly the stroke risk in DMD-patients. However, data about therapeutic opportunities in the acute setting are scarce in literature.