Publications by authors named "Charlotte Soulard"
Article Synopsis
- Synthetic OligoNucleotides (ON) are emerging as effective therapeutic tools for targeting genetic expression in various diseases, but challenges exist in their controlled release.
- Researchers developed Lipid-OligoNucleotide (LON) conjugates that form stable hydrogels, characterized by unique properties observed through advanced imaging techniques.
- These LON conjugates allow for a longer release of therapeutic sequences after being administered under the skin, offering a new method for sustained delivery of oligonucleotides without the need for additional substances.
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.
Antimicrob Agents Chemother
February 2012
Filibuvir and VX-222 are nonnucleoside inhibitors (NNIs) that bind to the thumb II allosteric pocket of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. Both compounds have shown significant promise in clinical trials and, therefore, it is relevant to better understand their mechanisms of inhibition. In our study, filibuvir and VX-222 inhibited the 1b/Con1 HCV subgenomic replicon, with 50% effective concentrations (EC(50)s) of 70 nM and 5 nM, respectively.
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