An extract from wild green oat improves rat behaviour.

An extract of wild green oat (Avena sativa L.), was tested in vivo in rats for its behavioural effects after chronic oral administration via extract-admixed food. Thirty six male Sprague-Dawley rats received (A) standard diet (controls), (B) 10 g/kg extract-admixed food or (C) 100 g/kg extract-admixed food.

A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity.

Background: Despite the availability of efficacious drugs, the success of treating hypertension is limited by patients' inconsistent drug intake. Immunization against angiotensin II may offer a valuable alternative to conventional drugs for the treatment of hypertension, because vaccines induce relatively long-lasting effects and do not require daily dosing. Here we describe the preclinical development and the phase I clinical trial testing of a virus-like particle (VLP)-based antihypertensive vaccine.