Publications by authors named "Charlotte Planta"
Article Synopsis
- A study is investigating whether flow cytometric analysis of myeloperoxidase expression in peripheral blood can accurately rule out myelodysplastic neoplasm (MDS), potentially reducing unnecessary bone marrow aspirations for about 35% of patients.
- The MPO-MDS-Valid project involves recruiting 400 patients from multiple hospitals in France to validate the testing method by comparing it to established diagnoses made by experienced hematopathologists.
- The research has been ethically approved, and results will be shared through publication to inform medical practice and improve patient care.
Flow cytometry lyophilised-reagent tube for quantifying peripheral blood neutrophil myeloperoxidase expression in myelodysplastic syndromes (MPO-MDS-Develop): protocol for a diagnostic accuracy study.
Tatiana Raskovalova Laura Scheffen Marie-Christine Jacob Simon Chevalier Sylvie Tondeur Charlotte Planta
BMJ Open
October 2022
Introduction: Suspicion of myelodysplastic syndromes (MDS) is the most common reason for bone marrow aspirate in elderly patients. Peripheral blood neutrophil myeloperoxidase expression quantified by flow cytometric analysis might rule out MDS for up to 35% of patients referred for suspected disease, without requiring bone marrow aspiration. Yet laboratory-developed liquid antibody cocktails have practical limitations, because of lack of standardisation and poor stability.
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