Publications by authors named "Charlotte Peloso"
and Hydrolytic Degradation Behaviors of a Drug-Delivery System Based on the Blend of PEG and PLA Copolymers.
ACS Appl Mater Interfaces
December 2023
This paper presents the and degradation of BEPO, a marketed forming depot technology used for the formulation of long-acting injectables. BEPO is composed of a solution of a blend of poly(ethylene glycol)--poly(lactic acid) (PEG-PLA) triblock and diblock in an organic solvent, where a therapeutic agent may be dissolved or suspended. Upon contact with an aqueous environment, the solvent diffuses and the polymers precipitate, entrapping the drug and forming a reservoir.
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- The study investigates the safety and tolerability of an in situ forming depot (ISFD) technology in Göttingen minipigs, focusing on injection flow rates and volumes.
- Observations over 10 days showed no significant adverse effects at injection sites, with both macroscopic and microscopic examinations confirming the safety of the procedure.
- The histopathological analysis noted predictable foreign body reactions that varied with injection volume, but overall indicated that the ISFD BEPO technology is safe for subcutaneous use in this animal model.
The diversity of microtubule functions is dependent on the status of tubulin C-termini. To address the physiological role of the C-terminal aromatic residue of α-tubulin, a tub1-Glu yeast strain expressing an α-tubulin devoid of its C-terminal amino acid was used to perform a genome-wide-lethality screen. The identified synthetic lethal genes suggested links with endocytosis and related processes.
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