Publications by authors named "Charlotte Neuerburg"
Article Synopsis
- A study was conducted to analyze the effects of omitting standard antibiotic prophylaxis during allogeneic hematopoietic stem cell transplantation (allo-HSCT), focusing on survival rates and the development of Graft-versus-Host disease (GvHD).
- The research compared patient outcomes before and after the suspension of antibiotic prophylaxis, assessing factors such as severe infections, transplant-related mortality, and infections by multiresistant pathogens among 221 patients.
- The results showed a trend towards better outcomes in the group without antibiotic prophylaxis; however, there were no significant differences found in overall survival or acute GvHD between the two groups.
To investigate the efficacy and toxicities of CPX-351 outside a clinical trial, we analyzed 188 patients (median age 65 years, range 26-80) treated for therapy-related acute myeloid leukemia (t-AML, 29%) or AML with myelodysplasia-related changes (AML-MRC, 70%). Eighty-six percent received one, 14% two induction cycles, and 10% received consolidation (representing 22% of patients with CR/CRi) with CPX-351. Following induction, CR/CRi rate was 47% including 64% of patients with available information achieving measurable residual disease (MRD) negativity (<10) as measured by flow cytometry.
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