Publications by authors named "Charlotte Jordan"
Article Synopsis
- Congenital stationary night blindness (CSNB) is a genetic eye condition often linked to high myopia, which can lead to serious retinal issues, making understanding myopic progression crucial for potential treatments.
- The study analyzed cases of CSNB associated with specific genetic variants in patients under 18 who had multiple eye measurements, using a mixed-effect model to track changes in myopia over time.
- Results showed that individuals with CSNB are significantly myopic from birth and continue to experience worsening myopia as they grow, suggesting they may benefit from treatments aimed at slowing down myopia progression.
Purpose: To examine the frequency of recurrence and identify risk factors for recurrence in patients with acute anterior uveitis (AAU).
Design: Retrospective cohort study from a single tertiary ophthalmic clinical center.
Participants: All subjects with AAU identified from a database of Inflammatory Eye Disease presenting to Te Whatu Ora (Auckland, New Zealand) between 2008 and 2021.
Purpose: To identify rates of uveitis reactivation both before and after the coronavirus disease (COVID) 2019 vaccine in subjects with a previous diagnosis of uveitis.
Design: Retrospective study.
Participants: Subjects were identified from the Inflammatory Eye Disease Registry at Auckland District Health Board diagnosed with uveitis between January 1, 2010, and December 31, 2020.
Background: Few studies have evaluated corneal crosslinking (CXL) in a prospective, randomised fashion. This study aimed to determine the efficacy and safety of CXL to reduce the progression of keratoconus.
Methods: Prospective, unmasked, randomised, contralateral eye controlled trial at a tertiary eye centre.
Purpose: To analyze corneal haze after corneal collagen crosslinking (CXL) for progressive keratoconus using Scheimpflug densitometry.
Setting: Auckland District Health Board, Auckland, New Zealand.
Design: Prospective randomized controlled study.
Purpose: Mutations in the zinc finger protein gene ZNF469 cause recessive brittle cornea syndrome, characterized by spontaneous corneal perforations. Genome-wide association studies (GWAS) have implicated common variants in this gene as a determinant for central corneal thickness (CCT). We investigated the contribution of ZNF469 in a sample set of keratoconus patients.
View Article and Find Full Text PDFPurpose: To use in vivo confocal microscopy (IVCM) to quantitatively analyze microstructural changes over time, after corneal collagen cross-linking for keratoconus.
Design: Prospective cohort study.
Participants: A total of 38 eyes of 38 patients undergoing collagen cross-linking for keratoconus.
Purpose: Mutations in the visual system homeobox 1 (VSX1) gene have been described at a low frequency in keratoconus and posterior polymorphous corneal dystrophy (PPCD). The putative role is controversial for several reasons, including a lack of mutations detected in other population cohorts. This study aims to determine whether VSX1 contributes to the genetic pathogenesis of keratoconus and PPCD in a New Zealand population, and includes analysis of a Polynesian population.
View Article and Find Full Text PDFBackground: The aim was to identify potential factors associated with acute corneal hydrops in a New Zealand population with keratoconus referred to a hospital eye service.
Methods: In a single hospital centre, in a retrospective review, demographic and clinical features of subjects with keratoconus and corneal hydrops over a 17-year period were compared with an age- and gender-matched control group of subjects with keratoconus but no history of corneal hydrops.
Results: One hundred and one eyes of 101 subjects (mean age 24.
Purpose: In corneal refractive surgery, postoperative ectasia risk assessment routinely includes pachymetric analysis at the apex and thinnest point. We examined whether these data differ worldwide and constructed preliminary country-specific normative thresholds.
Design: This was a multicenter, cross-sectional study.
Purpose: To compare intraocular pressure (IOP) measurements after penetrating keratoplasty (PK) using Goldmann applanation tonometry (GAT; Haag-Streit USA), TonoPen XL (Reichert Inc), Pascal Dynamic Contour tonometer (PDCT; Swiss Microtechnology AG), and Ocular Response Analyzer (ORA; Reichert Inc) and to analyze effects and correlation of corneal thickness and curvature on these measurements.
Design: Prospective, cross-sectional study.
Settings: Departments of Ophthalmology, University of Auckland and Auckland District Health Board, New Zealand.
Purpose: To evaluate corneal tomographic features of keratoconus and associations between risk factors and disease phenotype in New Zealand.
Setting: Departments of Ophthalmology, University of Auckland and Auckland District Health Board, Auckland, New Zealand.
Design: Clinic-based, cross-sectional study.