Publications by authors named "Charlotte J Van Edom"
Background: Apixaban is increasingly used instead of vitamin K antagonists (VKAs) for long-term anticoagulation during HeartMate 3 (HM3) support. However, data on its pharmacokinetics in this context is lacking. We present real-world data on apixaban levels and outcomes in adult and pediatric HM3 patients, and evaluate our dosing strategy based on plasma sampling.
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- - The study aims to standardize antithrombotic management practices for patients on percutaneous mechanical circulatory support (pMCS), as bleeding and clotting issues significantly affect patient outcomes during procedures like veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and Impella™ use.
- - An online survey targeting European clinicians was conducted, gathering 105 responses from 26 countries, revealing that most clinicians followed local anticoagulation protocols, primarily using unfractionated heparin (UFH), but there was notable variation in anticoagulant targets and monitoring practices.
- - The findings indicate considerable inconsistency in antithrombotic practices across responding institutions, which may lead to different rates of
Percutaneous ventricular assist devices (pVADs) are increasingly being used because of improved experience and availability. The Impella (Abiomed), a percutaneous microaxial, continuous-flow, short-term ventricular assist device, requires meticulous postimplantation management to avoid the 2 most frequent complications, namely, bleeding and hemolysis. A standardized approach to the prevention, detection, and treatment of these complications is mandatory to improve outcomes.
View Article and Find Full Text PDFPurpose Of Review: Cardiogenic shock (CS) remains a very challenging condition with high mortality, despite the advances in therapeutic options. Haematological complications, including coagulopathy and haemolysis, frequently arise in these critically ill patients in CS, especially if they need percutaneous mechanical circulatory support (pMCS), and impair the outcome. This stresses the urgent need for further advancement of this field.
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