Antisense Activity across the Promoter is Required for -Mediated Silencing in the Imprinted Cluster.

Macro long non-coding RNAs (lncRNAs) play major roles in gene silencing in inprinted gene clusters. Within the imprinted cluster, the paternally expressed lncRNA downregulates its sense counterpart . To explore the mechanism of action of , we generated two new knock-in alleles to truncate upstream and downstream of the promoter.