Publications by authors named "Charlotte J Reames"
Unlabelled: Successful tuberculosis therapy requires treatment with an unwieldy multidrug combination for several months. Thus, there is a growing need to identify novel genetic vulnerabilities that can be leveraged to develop new, more effective antitubercular drugs. Consequently, recent efforts to optimize TB therapy have exploited Mtb chemical genetics to identify pathways influencing antibiotic efficacy, novel mechanisms of antibiotic action, and new targets for TB drug discovery.
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- * This study explored the relationship between Mtb's carbon metabolism and drug interactions by using gene knockdown mutants to analyze the effects of common antitubercular drugs, revealing that the bacterial metabolic state significantly influences drug efficacy.
- * The researchers identified ways to enhance rifampicin effectiveness when Mtb grows on cholesterol, providing insights that could help improve drug combinations and understanding of how laboratory results relate to real-world infection scenarios.
Article Synopsis
- * Researchers used a genetically diverse group of mice, known as the Collaborative Cross (CC), along with a library of bacterial mutants, to explore the relationship between bacterial genetics and host immunity.
- * Findings indicated that different mouse strains showed significant differences in their susceptibility to infection and immune responses, highlighting specific host-pathogen interactions that affect disease outcomes.