Publications by authors named "Charlotte H Sensinger"
J Clin Lipidol
October 2017
Article Synopsis
- Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder that significantly raises LDL cholesterol levels, leading to serious heart problems. Mipomersen, a drug that reduces LDL-C by targeting apolipoprotein B, has shown promise for treating this condition.
- In a study involving seven patients aged 12-18, those treated with mipomersen experienced notable reductions in LDL-C and apo B levels compared to those on placebo, with some patients transitioning to mipomersen from placebo showing improvements during the open-label extension phase.
- Despite the effectiveness of mipomersen in lowering cholesterol, issues with long-term treatment adherence were reported, highlighting the need for strategies to improve patient compliance.
