Publications by authors named "Charlotte Frazer-Morris"
Background: We have previously demonstrated that dietary saturated fatty acids (SFA), when compared to polyunsaturated fatty acids (PUFA), are preferentially partitioned into oxidation pathways. However, it remains unclear if this preferential handling is maintained when hepatocellular metabolism is shifted toward fatty acid (FA) esterification and away from oxidation, such as when hepatic de novo lipogenesis (DNL) is upregulated.
Aim: To investigate whether an acute upregulation of hepatic DNL influences dietary FA partitioning into oxidation pathways.
Article Synopsis
- Scientists used special techniques to study how glucose is used in cells that help control insulin, called β cells, in both mice and humans.
- They discovered that glucose is used similarly in both species, but humans produce much more lactate, which is a waste product.
- A specific protein called LDHB helps control how much lactate these cells make, and lower levels of this protein are linked to higher insulin levels in humans.