Publications by authors named "Charlotte Fournier"
Epidermal growth factor (EGF) signalling regulates normal epithelial and other cell growth, with EGF receptor (EGFR) overexpression reported in many cancers. However, the role of EGFR clusters in cancer and their dependence on EGF binding is unclear. We present novel single-molecule total internal reflection fluorescence microscopy of (i) EGF and EGFR in living cancer cells, (ii) the action of anti-cancer drugs that separately target EGFR and human EGFR2 (HER2) on these cells and (iii) EGFR-HER2 interactions.
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- "Floating ankle" injuries are complex, high-energy traumas with significant soft tissue damage, where treatment options include external fixation or a combination of fixation methods.
- Eight patients (7 males, 1 female) with Grade III open fractures were treated, involving immediate surgical intervention and long-term rehabilitation.
- Despite the treatments, only two patients returned to their previous jobs, with most facing varying levels of disability and one undergoing amputation, highlighting the challenging recovery process associated with these injuries.