Untangling the overlap between frailty and low lean mass: Data from Toulouse frailty day hospital.

Background: The decline in lean mass, observed in older people, has been frequently associated with frailty. This assumption has scarcely been assessed. This study explored the association between current proposed definitions of low lean mass and the Fried phenotype of frailty.

Effects of multidomain lifestyle intervention, omega-3 supplementation or their combination on physical activity levels in older adults: secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) randomised controlled trial.

Background/objectives: to investigate the effects of a 3-year multidomain lifestyle intervention, omega-3 supplementation or both on physical activity (PA) in older adults with subjective memory complaints.

Design/settings/subjects: the Multidomain Alzheimer Preventive Trial was a 3-year randomised controlled trial that enroled 1,680 community-dwelling adults aged 70 years or over, with subjective memory complaints. Participants were randomised to omega-3 supplementation (total daily dose of 800 mg docosahexanoic acid and up to 225 mg eicosapentanoic acid), multidomain intervention (nutritional and exercise counselling and cognitive training), omega-3 plus multidomain intervention or placebo with usual care.

Sarcopenia Screened by the SARC-F Questionnaire and Physical Performances of Elderly Women: A Cross-Sectional Study.

Objectives: Screening for sarcopenia in daily practice can be challenging. Our objective was to explore whether the SARC-F questionnaire is a valid screening tool for sarcopenia (defined by the Foundation for the National Institutes of Health [FNIH] criteria). Moreover, we evaluated the physical performance of older women according to the SARC-F questionnaire.

Indicators of oral nutritional supplements prescription in nursing home residents: A cross-sectional study.

Background & Aims: Identifying factors associated with oral nutritional supplement (ONS) prescription in nursing homes (NH) may help to treat malnutrition in this very old and vulnerable population.

Objectives: The aim of the study was to investigate if resident-related and NH-related characteristics were associated with ONS prescription.

Design: Cross-sectional study using medical and demographic data from 6275 NH residents and data on the structure and organization (e.

Searching for a relevant definition of sarcopenia: results from the cross-sectional EPIDOS study.

Background: The diversity of definitions proposed for sarcopenia has been rarely tested in the same population, and so far, their clinical utilities for predicting physical difficulties could not be clearly understood. Our objective is to report the prevalence of sarcopenia and the characteristics of sarcopenic community-dwelling older women according to the different definitions of sarcopenia currently proposed. We also assessed these definitions for their incremental predictive value over currently standard predictors for some self-reported difficulties in physical function and knee extension strength.

Impact of a therapeutic educational program on quality of life in Alzheimer's disease: results of a pilot study.

Background: Therapeutic patient education is expanding in the field of Alzheimer's disease (AD).

Objective: To evaluate the impact of a therapeutic educational program, on AD-affected patients and their caregivers, living in the community, on the patient's quality of life.

Methods: Non experimental before and after study.

Association of a 7-year percent change in fat mass and muscle mass with subsequent cognitive dysfunction: the EPIDOS-Toulouse cohort.

Background: Cognitive dysfunction and changes in body composition share common pathophysiological pathways. The aim of the present paper was to evaluate whether changes in appendicular muscle mass (AMM) and fat mass (FM) are associated factors with an increased risk of cognitive dysfunction in community-dwelling older women.

Methods: A nested case-control study was performed in 181 women aged 75 years and older from a subsample of the Epidemiologie de l'Osteoporose participants from Toulouse.

A follow-up intervention in severely demented patients after discharge from a special Alzheimer acute care unit: impact on early emergency room re-hospitalization rate.

Background: Emergency room (ER) re-hospitalizations are prevalent in severe Alzheimer's disease affected older patients.

Design: Quasi-experimental before and after study.

Setting: Discharge of severely demented patients from a Special Alzheimer Acute Care Unit.

Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort.

Background: common pathophysiological pathways are shared between age-related body composition changes and cognitive impairment.

Objective: evaluate whether current operative sarcopenia definitions are associated with cognition in community-dwelling older women.

Design: cross-sectional analyses.

Clinical trials on sarcopenia: methodological issues regarding phase 3 trials.

Phase 3 trials estimate the effectiveness of an intervention to prevent, delay the onset of, or treat sarcopenia. Participants should have sarcopenia or present a sarcopenia risk profile. Control group should be characterized by the best standard of clinical care.

Treatment strategies for sarcopenia and frailty.

Sarcopenia is the key feature of frailty in older people and a major determinant of adverse health outcomes such as functional limitations and disability. Resistance training and adequate protein and energy intake are the key strategies for the management of sarcopenia. Management of weight loss and resistance training are the most relevant protective countermeasures to slow down the decline of muscle mass and muscle strength.