Publications by authors named "Charlotte Dahl Christiansen"
Article Synopsis
- Focal congenital hyperinsulinism (CHI) can be cured through surgery, making the identification of the focal lesion critical. This study compares the diagnostic effectiveness of 18F-DOPA PET/CT and 68Ga-DOTANOC PET/CT for detecting focal CHI.
- The research involved retrospective evaluations of PET/CT scans from CHI patients, using histology and genetic profiles as reference standards, revealing that 18F-DOPA PET/CT had a significantly higher predictive accuracy than 68Ga-DOTANOC PET/CT.
- The findings indicate that 18F-DOPA PET/CT is highly effective in identifying focal CHI, with accuracy in lesion localization, whereas the use of 68Ga-DOT
Background/aims: Congenital hyperinsulinism (CHI) is a heterogeneous disease most frequently caused by KATP-channel (ABCC8 and KCNJ11) mutations, with neonatal or later onset, variable severity, and with focal or diffuse pancreatic involvement as the two major histological types. CHI confers a high risk of neurological impairment; however, sparsely studied in larger patient series. We assessed the neurodevelopmental outcome in children with CHI at follow-up in a mixed international cohort.
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