Publications by authors named "Charlotte Crowe"
Article Synopsis
- Small-molecule degraders can effectively target and degrade disease-driving proteins, offering a new approach for treating previously untreatable conditions.
- Researchers used cryo-EM to observe how the degrader MZ1 helps position the Brd4 protein for ubiquitination by the UBE2R1 enzyme, leading to its degradation.
- The study identifies specific lysines on Brd4 that are prone to ubiquitination and suggests a flexible model for how degrader-induced targets could be modified for better drug development.
The enzymatic generation of carbon-halogen bonds is a powerful strategy used by both nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of compounds, opening up the opportunity for selective C-H functionalisation. Genes encoding halogenase enzymes have recently been shown to transcend all kingdoms of life. These enzymes install halogen atoms into aromatic and less activated aliphatic substrates, achieving selectivities that are often challenging to accomplish using synthetic methodologies.
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