Evolutionary biology and development model of medicines: A necessary 'pas de deux' for future successful bacteriophage therapy.

The increase in frequency of multidrug-resistant bacteria worldwide is largely the result of the massive use of antibiotics in the second half of the 20th century. These relatively recent changes in human societies revealed the great evolutionary capacities of bacteria towards drug resistance. In this article, we hypothesize that the success of future antibacterial strategies lies in taking into account both these evolutionary processes and the way human activities influence them.

"French Phage Network" Annual Conference 2018-Fourth Meeting Report.

The present meeting report aims to cover the scientific activities of the 4th French Bacteriophage Network (Phages.fr) symposium which took place during 24th-25th September 2018, at the Agora du Haut-Carré in Talence (France). The hosting institute was University Bordeaux and 72 participants attended the meeting from both public and private sectors, coming from France, Belgium, Ireland, Germany, Portugal and Canada.

[A century of research on bacteriophages].

Bacteriophages have a prominent place in the living world. They participate to our understanding of the living world through three main aspects : (i) the dissection of the most intimist aspects of viral infection molecular mechanisms (molecular biology), (ii) the description and functioning mechanisms of ecosystems (ecology), and (iii) the adaptive dynamics of integrated viral and host-cell populations (evolution). This review looks back at the genesis of these fundamental findings and draws a picture of the most active fields of current research.

[Antibacterial applications of bacteriophages].

In the 1917 article in which Félix d'Hérelle describes his first observations and proposes the name of bacteriophage, he also reports the first use of these viruses to treat bacterial infections, thus giving birth to phage therapy. Soon after antibiotics supplanted bacteriophages. Today, bacteria resistant to multiple antibiotics become a growing public health issue worldwide.

The myth of a naturalised male circumcision: Heuristic context and the production of scientific objects.

In March, 2007, the WHO and UNAIDS established a joint recommendation at the Montreux technical consultation, making male circumcision the first surgery to be used as a preventative tool against an infectious disease. This recommendation was immediately followed by the publication of numerous articles denouncing its content, leading to two distinct controversies, one between epidemiologists, and a second between epidemiologists and social scientists. Interestingly, however, none of these works took male circumcision as an issue in itself, exploring neither that both epidemiologists and social scientists had taken the object 'circumcision' as a given, nor what each party was referring to when talking about circumcision.