Publications by authors named "Charlotte Brandts"
Pharmacoeconomics
December 2021
Article Synopsis
- The National Institute for Health and Care Excellence (NICE) requested Gilead to provide evidence on the clinical and cost effectiveness of filgotinib (Jyseleca) for treating moderate to severe rheumatoid arthritis during their appraisal process.
- Kleijnen Systematic Reviews Ltd, with Maastricht University Medical Centre, was tasked with reviewing this evidence, which included a critical assessment of the company's submission and key methodological issues.
- The evidence for filgotinib came from two international trials and involved complex network meta-analyses due to a lack of direct comparisons, although results were uncertain due to variability in the studies.
Article Synopsis
- In 2008, guidelines were established for researching autophagy, which has since gained significant interest and new technologies, necessitating regular updates to monitoring methods across various organisms.
- The new guidelines emphasize selecting appropriate techniques to evaluate autophagy while noting that no single method suits all situations; thus, a combination of methods is encouraged.
- The document highlights that key proteins involved in autophagy also impact other cellular processes, suggesting genetic studies should focus on multiple autophagy-related genes to fully understand these pathways.
